Concepedia

Cell-substrate Stiffness Sensing

Cell-Substrate Stiffness Sensing is a cellular mechanotransduction process in which cells detect and respond to the mechanical rigidity of their underlying extracellular matrix through force-sensitive integrin-mediated adhesions and cytoskeletal remodeling.

218

Publications

18.9K

Citations

1.2K

Authors

386

Institutions

Publications per year

2017–2026

111

Parents

Publications

218

Myotubes differentiate optimally on substrates with tissue-like stiffness

Adam J. Engler, Maureen A. Griffin, Shamik Sen et al. · The Journal of Cell Biology · 2004 · 1.7K citations · Full text

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Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates

Jérôme Solon, Ilya Levental, Kheya Sengupta et al. · Biophysical Journal · 2007 · 1K citations · Full text

, , +16

Interplay of matrix stiffness and protein tethering in stem cell differentiation

Jessica H. Wen, Ludovic G. Vincent, Alexander Fuhrmann et al. · Nature Materials · 2014 · 942 citations · Full text

, , +16

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

Sergey V. Plotnikov, Ana M. Pasapera, Benedikt Sabass et al. · Cell · 2012 · 868 citations · Full text

, , +16

Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

Léa Trichet, Jimmy Le Digabel, Raymond J. Hawkins et al. · Proceedings of the National Academy of Sciences · 2012 · 537 citations · Full text

, , +17

1–5 of 218

Authors

1.2K

  1. KF
    Kristian Franze

    University of Cambridge, United Kingdom

    5 publications · 484 citations

    5

    h-index

  2. JX
    Jing Xie

    Sichuan University, China

    5 publications · 204 citations

    5

    h-index

  3. SS
    Shamik Sen

    Indian Institute of Technology Bombay, India

    5 publications · 1.9K citations

    5

    h-index

  4. AJ
    Adam J. Engler

    University of California San Diego, United States

    5 publications · 3.2K citations

    5

    h-index

  5. CZ
    Chenchen Zhou

    Sichuan University, China

    4 publications · 189 citations

    4

    h-index

1–5 of 1.2K

Institutions

386

  1. University of Pennsylvania

    Philadelphia, United States

    10 h-index

    33 publications

    19.5K citations

  2. Johns Hopkins University

    Baltimore, United States

    9 h-index

    28 publications

    1.5K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    36 publications

    7.1K citations

  4. Sichuan University

    Chengdu, China

    8 h-index

    34 publications

    1.7K citations

  5. Boston University

    Boston, United States

    7 h-index

    20 publications

    2.3K citations

  6. University of California, Berkeley

    Berkeley, United States

    7 h-index

    25 publications

    1.4K citations

  7. University of Cambridge

    Cambridge, United Kingdom

    7 h-index

    36 publications

    2.7K citations

  8. National University of Singapore

    Singapore, Singapore

    6 h-index

    20 publications

    3.8K citations

1–8 of 386

Venues

  1. Journal of Cell Science

    10 publications · 1.2K citations

    10

    h-index

  2. Soft Matter

    11 publications · 773 citations

    10

    h-index

  3. PLoS ONE

    9 publications · 553 citations

    9

    h-index

  4. Scientific Reports

    9 publications · 805 citations

    9

    h-index

  5. Molecular Biology of the Cell

    MBC · 8 publications · 526 citations

    8

    h-index

1–5