Concepedia

Cell-based Enzyme Screening

Cell-Based Enzyme Screening is a methodological approach in enzyme discovery that involves the functional assessment of enzyme activity within living cells, distinguishing it from in vitro or cell-free systems by leveraging the native cellular environment to maintain physiological relevance and enable phenotypic readouts.

32

Publications

1.2K

Citations

188

Authors

59

Institutions

Publications per year

2017–2026

6

Parents

Publications

32

High-Throughput Screening of Enzyme Libraries: Thiolactonases Evolved by Fluorescence-Activated Sorting of Single Cells in Emulsion Compartments

Amir Aharoni, Gil Amitai, Shlomo Magdassi et al. · Chemistry & Biology · 2005 · 228 citations · Full text

, , +17

Single‐Cell High‐Throughput Screening To Identify Enantioselective Hydrolytic Enzymes

Stefan Becker, Horst Höbenreich, Andreas Vogel et al. · Angewandte Chemie International Edition · 2008 · 87 citations

, , +17

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

Hao Zhang, Sai Ba, Divyanshu Mahajan et al. · Nano Letters · 2018 · 85 citations · Full text

, , +17

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

Ehud Goldin, Wei Zheng, Omid Motabar et al. · PLoS ONE · 2012 · 70 citations · Full text

, , +17

Differential assay of arylsulfatase A and B activities: A sensitive method for cultured human cells

Patricia L. Chang, Nadia E. Rosa, Ronald G. Davidson · Analytical Biochemistry · 1981 · 63 citations

, , +16

1–5 of 32

Authors

188

  1. WZ
    Wei Zheng

    National Institutes of Health, United States

    4 publications · 153 citations

    4

    h-index

  2. BS
    Berta Strulovici

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    2 publications · 69 citations

    2

    h-index

  3. EM
    Edward M. Scolnick

    National Cancer Institute, United States

    2 publications · 69 citations

    2

    h-index

  4. MW
    Marco W. Fraaije

    University of Groningen, Netherlands

    2 publications · 23 citations

    2

    h-index

  5. JM
    Juan Marugán

    National Center for Advancing Translational Sciences, United States

    2 publications · 84 citations

    2

    h-index

1–5 of 188

Institutions

59

  1. University of Chinese Academy of Sciences

    Beijing, China

    2 h-index

    4 publications

    107 citations

  2. ETH Zurich

    Zurich, Switzerland

    2 h-index

    6 publications

    150 citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    14 publications

    644 citations

  4. University of Groningen

    Groningen, The Netherlands

    2 h-index

    6 publications

    70 citations

  5. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    7 publications

    168 citations

  6. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    9 publications

    281 citations

  7. RWTH Aachen University

    Aachen, Germany

    2 h-index

    6 publications

    106 citations

  8. Kitasato University

    Tokyo, Japan

    1 h-index

    6 publications

    108 citations

1–8 of 59

Venues

  1. Analytical Biochemistry

    4 publications · 144 citations

    4

    h-index

  2. SLAS DISCOVERY

    3 publications · 81 citations

    3

    h-index

  3. PLoS ONE

    3 publications · 99 citations

    3

    h-index

  4. Biotechnology and Bioengineering

    3 publications · 78 citations

    3

    h-index

  5. Analytical Chemistry

    1 publications · 44 citations

    1

    h-index

1–5