Concepedia

Catechol-o-methyltransferase Pathways

Catechol-O-Methyltransferase Pathways is a biochemical degradation pathway that catalyzes the methylation of catecholamine neurotransmitters and their metabolites through the action of the enzyme catechol-O-methyltransferase, thereby regulating their inactivation and clearance in neural and peripheral tissues.

772

Publications

51.4K

Citations

3K

Authors

841

Institutions

Publications per year

2017–2026

55

Variants

Comt Pathways

Parents

Publications

772

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase

Stefan L. Marklund, Gudrun MARKLUND · European Journal of Biochemistry · 1974 · 10.3K citations · Full text

, , +16

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

Jingshan Chen, Barbara K. Lipska, Nader D. Halim et al. · The American Journal of Human Genetics · 2004 · 1.7K citations · Full text

, , +10

Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction

Avshalom Caspi, Terrie E. Moffitt, Mary Cannon et al. · Biological Psychiatry · 2005 · 1.4K citations

, , +17

Enzymatic O-Methylation of Epinephrine and Other Catechols

Julius Axelrod, Robert Tomchick · Journal of Biological Chemistry · 1958 · 1.3K citations · Full text

, , +14

Catechol <i>O</i> -methyltransferase <i>val</i> <sup> <i>158</i> </sup> <i>-met</i> genotype and individual variation in the brain response to amphetamine

Venkata S. Mattay, Terry E. Goldberg, Francesco Saverio Fera et al. · Proceedings of the National Academy of Sciences · 2003 · 896 citations

, , +15

1–5 of 772

Authors

3K

  1. PT
    Pekka T. Männistö

    University of Helsinki, Finland

    25 publications · 1.6K citations

    21

    h-index

  2. PS
    Patrı́cio Soares-da-Silva

    Bial (Portugal), Portugal

    18 publications · 784 citations

    16

    h-index

  3. MJ
    Maria João Bonifácio

    Bial (Portugal), Portugal

    12 publications · 476 citations

    12

    h-index

  4. RT
    Ronald T. Borchardt

    University of Kansas, United States

    14 publications · 623 citations

    12

    h-index

  5. DR
    Daniel R. Weinberger

    National Institute of Mental Health, United States

    12 publications · 3.6K citations

    12

    h-index

1–5 of 3K

Institutions

841

  1. Orion Corporation (Finland)

    Espoo, Finland

    24 h-index

    96 publications

    6.6K citations

  2. University of Helsinki

    Helsinki, Finland

    23 h-index

    101 publications

    4.5K citations

  3. National Institute of Mental Health

    Bethesda, United States

    22 h-index

    107 publications

    22.6K citations

  4. National Institutes of Health

    Bethesda, United States

    20 h-index

    109 publications

    33.5K citations

  5. Bial (Portugal)

    Porto, Portugal

    17 h-index

    69 publications

    3.6K citations

  6. Columbia University

    New York, United States

    15 h-index

    49 publications

    8.8K citations

  7. Roche (Switzerland)

    Basel, Switzerland

    15 h-index

    62 publications

    2.3K citations

  8. University of Eastern Finland

    Joensuu, Finland

    14 h-index

    50 publications

    3K citations

1–8 of 841

Venues

  1. Biological Psychiatry

    24 publications · 3.5K citations

    23

    h-index

  2. Biochemical Pharmacology

    32 publications · 1K citations

    19

    h-index

  3. Journal of Medicinal Chemistry

    22 publications · 756 citations

    17

    h-index

  4. PubMed

    Repository · 24 publications · 1.1K citations

    16

    h-index

  5. Life Sciences

    17 publications · 631 citations

    16

    h-index

1–5