Concepedia

Catalytic Tetrads

Catalytic Tetrads is a structural motif in enzyme active sites comprising four precisely arranged amino acid residues that cooperatively participate in catalysis, distinguished from catalytic triads by the inclusion of an additional residue to enhance or modulate catalytic efficiency and mechanism.

13

Publications

865

Citations

44

Authors

23

Institutions

Publications per year

2017–2026

1

Parents

Publications

13

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

Richard Obexer, Xavier Garrabou, Peer R. E. Mittl et al. · Nature Chemistry · 2016 · 319 citations

, , +14

Ethylene−Norbornene Copolymers from Metallocene-Based Catalysts:  Microstructure at Tetrad Level and Reactivity Ratios

Incoronata Tritto, Laura Boggioni, Johannes C. Jansen et al. · Macromolecules · 2001 · 116 citations

, , +17

Rapid intersite transfer of acetyl groups and movement of pyruvate dehydrogenase component in the kidney pyruvate dehydrogenase complex.

Richard L. Cate, T.E. Roche, Lawrence C. Davis · Journal of Biological Chemistry · 1980 · 78 citations · Full text

, , +11

Tetrameric Structure of a Serine Integrase Catalytic Domain

Peng Yuan, Kushol Gupta, Gregory D. Van Duyne · Structure · 2008 · 67 citations · Full text

, , +14

Engineering Steroid 5β-Reductase Activity into Rat Liver 3α-Hydroxysteroid Dehydrogenase

Joseph M. Jez, T.M. Penning · Biochemistry · 1998 · 64 citations

, , +17

1–5 of 13

Authors

44

  1. IT
    Incoronata Tritto

    Institute for Macromolecular Studies, Italy

    2 publications · 147 citations

    2

    h-index

  2. MC
    Maria Carmela Sacchi

    Istituto di Chimica Biomolecolare, Italy

    2 publications · 129 citations

    2

    h-index

  3. LB
    Laura Boggioni

    Institute for Macromolecular Studies, Italy

    2 publications · 147 citations

    2

    h-index

  4. DR
    Dino R. Ferro

    Istituto di Chimica Biomolecolare, Italy

    2 publications · 147 citations

    2

    h-index

  5. DB
    David Baker

    University of Washington, United States

    1 publications · 319 citations

    1

    h-index

1–5 of 44

Institutions

23

  1. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    5 publications

    329 citations

  2. Institute for Macromolecular Studies

    Milan, Italy

    2 h-index

    8 publications

    176 citations

  3. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    2 publications

    70 citations

  4. University of Colorado Health

    Aurora, United States

    1 h-index

    3 publications

    48 citations

  5. Istituto di Chimica Biomolecolare

    Catania, Italy

    1 h-index

    6 publications

    696 citations

  6. Harvard University

    Cambridge, United States

    1 h-index

    3 publications

    234 citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    3 publications

    201 citations

  8. ETH Zurich

    Zurich, Switzerland

    1 h-index

    3 publications

    957 citations

1–8 of 23

Venues

  1. Macromolecules

    3 publications · 160 citations

    3

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 101 citations

    2

    h-index

  3. Molecular Genetics and Metabolism

    1 publications · 16 citations

    1

    h-index

  4. Nucleic Acids Research

    1 publications · 15 citations

    1

    h-index

  5. Nature Chemistry

    1 publications · 319 citations

    1

    h-index

1–5