Concepedia

Catalytic Cycle Dynamics

Catalytic Cycle Dynamics is a theoretical framework that characterizes the time-dependent conformational and energetic changes of enzyme-substrate complexes throughout the sequential stages of a catalytic cycle, distinguishing itself by integrating transient structural states and kinetic transitions to elucidate mechanistic pathways in enzyme catalysis.

418

Publications

24.3K

Citations

1.8K

Authors

546

Institutions

Publications per year

2017–2026

109

Parents

Publications

418

The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis

David D. Boehr, Dan McElheny, H. Jane Dyson et al. · Science · 2006 · 961 citations

, , +17

Loop and Subdomain Movements in the Mechanism of <i>Escherichia coli </i>Dihydrofolate Reductase:  Crystallographic Evidence<sup>,</sup>

M.R. Sawaya, Joseph Kraut · Biochemistry · 1997 · 666 citations

, , +17

“Turning Over” Definitions in Catalytic Cycles

Sebastian Kozuch, Jan M. L. Martin · ACS Catalysis · 2012 · 639 citations

, , +16

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

Arnold J. M. Driessen, F. Ulrich Hartl, William Wickner · Cell · 1991 · 463 citations

, , +10

Single-Molecule Kinetics of λ Exonuclease Reveal Base Dependence and Dynamic Disorder

Antoine M. van Oijen, Paul C. Blainey, Donald J. Crampton et al. · Science · 2003 · 377 citations · Full text

, , +17

1–5 of 418

Authors

1.8K

  1. HJ
    H. Jane Dyson

    Scripps Research Institute, United States

    7 publications · 1.6K citations

    7

    h-index

  2. PE
    Peter E. Wright

    Scripps Research Institute, United States

    7 publications · 1.6K citations

    7

    h-index

  3. DD
    David D. Boehr

    Pennsylvania State University, United States

    5 publications · 1.2K citations

    5

    h-index

  4. PJ
    Paul J. Dauenhauer

    University of Minnesota, United States

    5 publications · 383 citations

    5

    h-index

  5. AS
    Alexander S. Mikhailov

    Fritz Haber Institute of the Max Planck Society, Germany

    4 publications · 98 citations

    4

    h-index

1–5 of 1.8K

Institutions

546

  1. Centre National de la Recherche Scientifique

    Paris, France

    20 h-index

    79 publications

    3.6K citations

  2. University of Minnesota

    Minneapolis, United States

    13 h-index

    41 publications

    4.2K citations

  3. Chinese Academy of Sciences

    Beijing, China

    12 h-index

    84 publications

    7.8K citations

  4. Scripps Research Institute

    San Diego, United States

    11 h-index

    47 publications

    8.5K citations

  5. University of California San Diego

    San Diego, United States

    10 h-index

    22 publications

    2.6K citations

  6. University of Oxford

    Oxford, United Kingdom

    9 h-index

    36 publications

    2.2K citations

  7. Stanford University

    Stanford, United States

    8 h-index

    26 publications

    1.7K citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    7 h-index

    16 publications

    672 citations

1–8 of 546

Venues

  1. Journal of the American Chemical Society

    JACS · 52 publications · 4.6K citations

    39

    h-index

  2. Journal of Biological Chemistry

    JBC · 28 publications · 1.5K citations

    24

    h-index

  3. Biochemistry

    39 publications · 2.2K citations

    22

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 2K citations

    22

    h-index

  5. ACS Catalysis

    15 publications · 1.5K citations

    12

    h-index

1–5