Concepedia

Cardiac Sarcomere Function

Cardiac Sarcomere Function is a physiological construct that refers to the molecular mechanism governing force generation and contraction in cardiac muscle through the regulated interaction of actin and myosin filaments within the sarcomere, distinguishing it from skeletal or smooth muscle sarcomere function by its calcium-dependent regulation and intrinsic role in modulating heart muscle contractility.

336

Publications

22.7K

Citations

1.9K

Authors

512

Institutions

Publications per year

2017–2026

90

Parents

Publications

336

α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere

Ludwig Thierfelder, Hugh Watkins, Calum A. MacRae et al. · Cell · 1994 · 1K citations

, , +10

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Eric M. Green, Hiroko Wakimoto, Robert L. Anderson et al. · Science · 2016 · 709 citations · Full text

, , +15

Cardiac troponin T is essential in sarcomere assembly and cardiac contractility

Amy J. Sehnert, Anja Huq, Brant M. Weinstein et al. · Nature Genetics · 2002 · 651 citations

, , +10

Mutations in the gamma2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

Edward Blair · Human Molecular Genetics · 2001 · 530 citations · Full text

, , +14

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Alexandre J. S. Ribeiro, Yen-Sin Ang, Ji‐Dong Fu et al. · Proceedings of the National Academy of Sciences · 2015 · 488 citations · Full text

, , +17

1–5 of 336

Authors

1.9K

  1. RJ
    R. John Solaro

    University of Illinois Chicago, United States

    17 publications · 932 citations

    17

    h-index

  2. PP
    Pieter P. de Tombe

    University of Illinois Chicago, United States

    12 publications · 870 citations

    12

    h-index

  3. CE
    Christine E. Seidman

    Harvard University, United States

    9 publications · 2.5K citations

    9

    h-index

  4. JM
    Joseph M. Metzger

    University of Michigan, United States

    9 publications · 385 citations

    9

    h-index

  5. HG
    Henk Granzier

    University of Arizona, United States

    9 publications · 853 citations

    9

    h-index

1–5 of 1.9K

Institutions

512

  1. University of Illinois Chicago

    Chicago, United States

    18 h-index

    106 publications

    6.3K citations

  2. University of Arizona

    Tucson, United States

    16 h-index

    69 publications

    4.7K citations

  3. Harvard University

    Cambridge, United States

    14 h-index

    61 publications

    11.6K citations

  4. Brigham and Women's Hospital

    Boston, United States

    13 h-index

    27 publications

    6K citations

  5. University of Michigan

    Ann Arbor, United States

    11 h-index

    37 publications

    1.9K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    23 publications

    7.4K citations

  7. University of Wisconsin–Madison

    Madison, United States

    11 h-index

    42 publications

    6K citations

  8. University of Oxford

    Oxford, United Kingdom

    10 h-index

    44 publications

    3.1K citations

1–8 of 512

Venues

  1. Circulation Research

    30 publications · 3.5K citations

    28

    h-index

  2. 22

    h-index

  3. Journal of Biological Chemistry

    JBC · 20 publications · 1.4K citations

    19

    h-index

  4. Journal of Molecular and Cellular Cardiology

    22 publications · 884 citations

    16

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.7K citations

    12

    h-index

1–5