Concepedia

Cap Hypermethylation

Cap Hypermethylation is a post-transcriptional RNA modification process in which additional methyl groups are enzymatically added to the 5′ cap structure of eukaryotic mRNA beyond the standard m⁷G cap, resulting in cap structures with multiple methylations on the ribose sugars of the first and sometimes second transcribed nucleotides.

30

Publications

2K

Citations

109

Authors

55

Institutions

Publications per year

2017–2026

5

Parents

Publications

30

Monomethylated cap structures facilitate RNA export from the nucleus

Jörg Hamm, Iain W. Mattaj · Cell · 1990 · 409 citations

, , +14

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal

Beáta E. Jády, Édouard Bertrand, Tamás Kiss · The Journal of Cell Biology · 2004 · 267 citations · Full text

, , +15

Hypermethylation of the Cap Structure of Both Yeast snRNAs and snoRNAs Requires a Conserved Methyltransferase that Is Localized to the Nucleolus

John Mouaikel, Céline Verheggen, Édouard Bertrand et al. · Molecular Cell · 2002 · 249 citations · Full text

, , +16

m <sub>3</sub> G Cap Hypermethylation of U1 Small Nuclear Ribonucleoprotein (snRNP) In Vitro: Evidence that the U1 Small Nuclear RNA-(Guanosine- <i>N</i> 2)-Methyltransferase Is a Non-snRNP Cytoplasmic Protein That Requires a Binding Site on the Sm Core Domain

Gabriele Plessel, Utz Fischer, Reinhard Lührmann · Molecular and Cellular Biology · 1994 · 100 citations · Full text

, , +11

mRNA ageing shapes the Cap2 methylome in mammalian mRNA

Vladimir Despic, Samie R. Jaffrey · Nature · 2023 · 77 citations · Full text

, , +14

1–5 of 30

Authors

109

  1. ÉB
    Édouard Bertrand

    Centre National de la Recherche Scientifique, France

    4 publications · 623 citations

    4

    h-index

  2. VH
    Victoria H. Cowling

    University of Dundee, United Kingdom

    4 publications · 228 citations

    4

    h-index

  3. CV
    Céline Verheggen

    Centre National de la Recherche Scientifique, France

    3 publications · 356 citations

    3

    h-index

  4. CK
    C. Kiong Ho

    Kettering University, United States

    2 publications · 50 citations

    2

    h-index

  5. TM
    Thomas Monecke

    University of Göttingen, Germany

    2 publications · 68 citations

    2

    h-index

1–5 of 109

Institutions

55

  1. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    19 publications

    2.2K citations

  2. University of Dundee

    Dundee, United Kingdom

    4 h-index

    14 publications

    644 citations

  3. Institut de Génétique Moléculaire de Montpellier

    Montpellier, France

    3 h-index

    13 publications

    2.1K citations

  4. University at Buffalo, State University of New York

    Buffalo, United States

    2 h-index

    6 publications

    170 citations

  5. Architecture et Réactivité de l'arN

    Strasbourg, France

    2 h-index

    12 publications

    516 citations

  6. Inserm

    Paris, France

    2 h-index

    6 publications

    160 citations

  7. Université de Strasbourg

    Strasbourg, France

    2 h-index

    11 publications

    501 citations

  8. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    9 publications

    192 citations

1–8 of 55

Venues

  1. Nucleic Acids Research

    9 publications · 275 citations

    9

    h-index

  2. Molecular and Cellular Biology

    MCB · 3 publications · 201 citations

    3

    h-index

  3. Oncogene

    2 publications · 136 citations

    2

    h-index

  4. Cell Reports

    2 publications · 85 citations

    2

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 80 citations

    2

    h-index

1–5