Concepedia

Canalicular Transporter Dysfunction

Canalicular Transporter Dysfunction is a pathological condition characterized by impaired activity of ATP-dependent membrane transporters localized to the hepatocyte canalicular membrane, leading to disrupted bile formation and cholestatic liver injury.

43

Publications

4.4K

Citations

241

Authors

91

Institutions

Publications per year

2017–2026

6

Parents

Publications

43

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

Coen C. Paulusma, Piter J. Bosma, Guido J.R. Zaman et al. · Science · 1996 · 832 citations

, , +17

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

Coen C. Paulusma, Marcel Kool, Piter J. Bosma et al. · Hepatology · 1997 · 557 citations · Full text

, , +17

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

Shojiro Kikuchi, Masaki Hata, Kanehisa Fukumoto et al. · Nature Genetics · 2002 · 308 citations

, , +13

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

Coen C. Paulusma, Michael A. van GEER, Raymond Evers et al. · Biochemical Journal · 1999 · 247 citations · Full text

, , +17

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

Ryan E. Morgan, Carlo J. van Staden, Yuan Chen et al. · Toxicological Sciences · 2013 · 239 citations · Full text

, , +17

1–5 of 43

Authors

241

  1. CC
    Coen C. Paulusma

    Amsterdam UMC Location University of Amsterdam, Netherlands

    6 publications · 1.9K citations

    6

    h-index

  2. RP
    Ronald P.J. Oude Elferink

    Amsterdam UMC Location University of Amsterdam, Netherlands

    4 publications · 1.3K citations

    4

    h-index

  3. PB
    Piet Borst

    The Netherlands Cancer Institute, Netherlands

    4 publications · 1.7K citations

    4

    h-index

  4. DK
    Dietrich Keppler

    German Cancer Research Center, Germany

    3 publications · 582 citations

    3

    h-index

  5. TA
    Tounsia Aït‐Slimane

    Inserm, France

    3 publications · 99 citations

    3

    h-index

1–5 of 241

Institutions

91

  1. Amsterdam UMC Location University of Amsterdam

    Amsterdam, The Netherlands

    6 h-index

    33 publications

    12K citations

  2. University of Amsterdam

    Amsterdam, The Netherlands

    4 h-index

    8 publications

    2K citations

  3. University of Groningen

    Groningen, The Netherlands

    3 h-index

    13 publications

    464 citations

  4. Inserm

    Paris, France

    3 h-index

    24 publications

    792 citations

  5. Assistance Publique – Hôpitaux de Paris

    Paris, France

    3 h-index

    3 publications

    99 citations

  6. German Cancer Research Center

    Heidelberg, Germany

    3 h-index

    8 publications

    1.3K citations

  7. DKFZ-ZMBH Alliance

    Heidelberg, Germany

    3 h-index

    8 publications

    1.3K citations

  8. National University of Rosario

    Rosario, Argentina

    3 h-index

    10 publications

    201 citations

1–8 of 91

Venues

  1. Hepatology

    8 publications · 940 citations

    8

    h-index

  2. Gastroenterology

    2 publications · 203 citations

    2

    h-index

  3. Archives of Toxicology

    2 publications · 25 citations

    2

    h-index

  4. Biochemical Journal

    BJ · 2 publications · 328 citations

    2

    h-index

  5. Gut

    2 publications · 158 citations

    2

    h-index

1–5