Concepedia

Calreticulin Cycle

The "Calreticulin Cycle" is a molecular chaperone-mediated quality control mechanism in the endoplasmic reticulum that specifically recognizes monoglucosylated N-glycans on nascent glycoproteins, facilitating their proper folding through iterative cycles of calreticulin binding and release regulated by glucosidase II and UDP-glucose:glycoprotein glucosyltransferase.

33

Publications

2.1K

Citations

191

Authors

86

Institutions

Publications per year

2017–2026

6

Parents

Publications

33

Malectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein <i>N</i> -Glycosylation

Thomas Schallus, Christine Jaeckh, Krisztina Fehér et al. · Molecular Biology of the Cell · 2008 · 288 citations · Full text

, , +17

Multiple Mechanism–Mediated Retention of a Defective Brassinosteroid Receptor in the Endoplasmic Reticulum of <i>Arabidopsis</i>

Zhi Hong, Hua Jin, Tzvi Tzfira et al. · The Plant Cell · 2008 · 185 citations · Full text

, , +14

More Than One Glycan Is Needed for ER Glucosidase II to Allow Entry of Glycoproteins into the Calnexin/Calreticulin Cycle

Paola Deprez, Matthias Gautschi, Ari Helenius · Molecular Cell · 2005 · 141 citations · Full text

, , +13

Persistent Glycoprotein Misfolding Activates the Glucosidase II/UGT1-Driven Calnexin Cycle to Delay Aggregation and Loss of Folding Competence

Maurizio Molinari, Carmela Galli, Omar Vanoni et al. · Molecular Cell · 2005 · 123 citations · Full text

, , +17

Endoplasmic Reticulum-associated Degradation of Mammalian Glycoproteins Involves Sugar Chain Trimming to Man6–5GlcNAc2

Zehavit Frenkel, Walter Gregory, Stuart Kornfeld et al. · Journal of Biological Chemistry · 2003 · 108 citations · Full text

, , +16

1–5 of 33

Authors

191

  1. ID
    Ivan D. Stigliano

    Universidad de Buenos Aires, Argentina

    2 publications · 100 citations

    2

    h-index

  2. YT
    Yoichi Takeda

    Tohoku University, Japan

    2 publications · 47 citations

    2

    h-index

  3. AH
    Ari Helenius

    Yale University, United States

    2 publications · 175 citations

    2

    h-index

  4. DB
    Danilo B. Medinas

    University of Chile, Chile

    2 publications · 113 citations

    2

    h-index

  5. CI
    Catherine I. Andreu

    Pontificia Universidad Católica de Chile, Chile

    2 publications · 113 citations

    2

    h-index

1–5 of 191

Institutions

86

  1. University of Michigan

    Ann Arbor, United States

    3 h-index

    9 publications

    1.1K citations

  2. University of Chile

    Santiago, Chile

    3 h-index

    28 publications

    1.5K citations

  3. University of Alberta

    Edmonton, Canada

    3 h-index

    5 publications

    183 citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    3 publications

    163 citations

  5. Fundación Instituto Leloir

    Buenos Aires, Argentina

    2 h-index

    6 publications

    280 citations

  6. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    2 h-index

    3 publications

    340 citations

  7. Institute of Oncology Research

    Bellinzona, Switzerland

    2 h-index

    2 publications

    181 citations

  8. Neurounion Biomedical Foundation

    Santiago, Chile

    2 h-index

    2 publications

    113 citations

1–8 of 86

Venues

  1. Journal of Biological Chemistry

    JBC · 6 publications · 428 citations

    6

    h-index

  2. PLoS ONE

    3 publications · 130 citations

    3

    h-index

  3. Molecular Biology of the Cell

    MBC · 3 publications · 388 citations

    3

    h-index

  4. Molecular Cell

    2 publications · 264 citations

    2

    h-index

  5. Cell Calcium

    1 publications · 28 citations

    1

    h-index

1–5