Concepedia

Brca1-dependent Damage Recognition

BRCA1-Dependent Damage Recognition is a molecular mechanism of DNA damage surveillance in which the BRCA1 tumor suppressor protein mediates the identification and recruitment of repair machinery to sites of genomic lesions, particularly double-strand breaks, through its specific interactions with phosphorylated adaptor proteins and chromatin modifications, thereby distinguishing it from BRCA1-independent pathways of damage sensing.

25

Publications

4.6K

Citations

144

Authors

63

Institutions

Publications per year

2017–2026

6

Parents

Publications

25

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

Yi Wang, David Cortez, Parvin T. Yazdi et al. · Genes & Development · 2000 · 1.2K citations · Full text

, , +16

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

Ralph Scully, Junjie Chen, Robert Ochs et al. · Cell · 1997 · 909 citations · Full text

, , +16

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Leeju C. Wu, Zhuo Wei Wang, Julia Tsou Tsan et al. · Nature Genetics · 1996 · 752 citations

, , +11

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

Julie A. Clapperton, Isaac A. Manke, Drew M. Lowery et al. · Nature Structural & Molecular Biology · 2004 · 255 citations

, , +11

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair

Anne‐Renee Hartman, James M. Ford · Nature Genetics · 2002 · 234 citations

, , +12

1–5 of 25

Authors

144

  1. RB
    Richard Baer

    Cancer Genetics (United States), United States

    2 publications · 790 citations

    2

    h-index

  2. JC
    Junjie Chen

    The University of Texas MD Anderson Cancer Center, United States

    2 publications · 1K citations

    2

    h-index

  3. AR
    Ashok R. Venkitaraman

    University of Cambridge, United Kingdom

    2 publications · 87 citations

    2

    h-index

  4. XY
    Xiaochun Yu

    University of Michigan, United States

    2 publications · 248 citations

    2

    h-index

  5. RS
    Ralph Schiess

    ETH Zurich, Switzerland

    1 publications · 66 citations

    1

    h-index

1–5 of 144

Institutions

63

  1. Medical Research Council

    London, United Kingdom

    3 h-index

    10 publications

    617 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    10 publications

    8K citations

  3. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    6 publications

    281 citations

  4. UPMC Hillman Cancer Center

    Pittsburgh, United States

    2 h-index

    4 publications

    177 citations

  5. University of Alberta

    Edmonton, Canada

    2 h-index

    7 publications

    249 citations

  6. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    8 publications

    498 citations

  7. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    8 publications

    483 citations

  8. Instituto Federal do Rio de Janeiro

    Rio de Janeiro, Brazil

    1 h-index

    2 publications

    44 citations

1–8 of 63

Venues

  1. Nature Structural & Molecular Biology

    2 publications · 407 citations

    2

    h-index

  2. Oncogene

    2 publications · 65 citations

    2

    h-index

  3. Molecular Cell

    2 publications · 177 citations

    2

    h-index

  4. Nature Genetics

    2 publications · 986 citations

    2

    h-index

  5. The EMBO Journal

    2 publications · 199 citations

    2

    h-index

1–5