Concepedia

Bliss Independence Analysis

Bliss Independence Analysis is a pharmacological metric used to evaluate the interaction between two antimicrobial agents by quantifying the deviation of their observed combined effect from the expected additive effect under the assumption of independence, based on the probabilistic principle that the combined effect of two independent events equals the sum of their individual effects minus the product of their probabilities.

61

Publications

3.8K

Citations

326

Authors

167

Institutions

Publications per year

2017–2026

26

Variants

Bliss IndependenceBliss Independence Model

Parents

Publications

61

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

Gregory M. Laird, C. Korin Bullen, Daniel I. S. Rosenbloom et al. · Journal of Clinical Investigation · 2015 · 404 citations · Full text

, , +15

A New Bliss Independence Model to Analyze Drug Combination Data

Wei Zhao, Kris F. Sachsenmeier, Lanju Zhang et al. · SLAS DISCOVERY · 2014 · 327 citations · Full text

, , +14

In Vitro Drug Interaction Modeling of Combinations of Azoles with Terbinafine against Clinical<i>Scedosporium prolificans</i>Isolates

Joseph Meletiadis, Johan W. Mouton, Jacques F. Meis et al. · Antimicrobial Agents and Chemotherapy · 2002 · 252 citations · Full text

, , +17

Statistical determination of synergy based on Bliss definition of drugs independence

Eugene Demidenko, Todd W. Miller · PLoS ONE · 2019 · 163 citations · Full text

, , +13

Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance

S. Alireza Rabi, Gregory M. Laird, Christine M. Durand et al. · Journal of Clinical Investigation · 2013 · 140 citations

, , +17

1–5 of 61

Authors

326

  1. JM
    Joseph Meletiadis

    National and Kapodistrian University of Athens, Greece

    8 publications · 658 citations

    8

    h-index

  2. JW
    Johan W. Mouton

    Erasmus MC, Netherlands

    7 publications · 641 citations

    7

    h-index

  3. PE
    Paul E. Verweij

    Radboud University Nijmegen, Netherlands

    6 publications · 533 citations

    6

    h-index

  4. ZT
    Zoltán Tóth

    University of Debrecen, Hungary

    4 publications · 147 citations

    4

    h-index

  5. RK
    Renátó Kovács

    University of Debrecen, Hungary

    4 publications · 147 citations

    4

    h-index

1–5 of 326

Institutions

167

  1. Radboud University Nijmegen

    Nijmegen, The Netherlands

    8 h-index

    39 publications

    3K citations

  2. National and Kapodistrian University of Athens

    Athens, Greece

    5 h-index

    13 publications

    458 citations

  3. Radboud University Medical Center

    Nijmegen, The Netherlands

    5 h-index

    32 publications

    2.5K citations

  4. University of Debrecen

    Debrecen, Hungary

    4 h-index

    24 publications

    869 citations

  5. Canisius-Wilhelmina Ziekenhuis

    Nijmegen, Netherlands

    4 h-index

    10 publications

    959 citations

  6. Cornell University

    Ithaca, United States

    4 h-index

    9 publications

    646 citations

  7. Uppsala University

    Uppsala, Sweden

    3 h-index

    3 publications

    141 citations

  8. University of Campania "Luigi Vanvitelli"

    Caserta, Italy

    3 h-index

    3 publications

    193 citations

1–8 of 167

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 9 publications · 686 citations

    9

    h-index

  2. Journal of Antimicrobial Chemotherapy

    JAC · 4 publications · 307 citations

    4

    h-index

  3. Medical Mycology

    3 publications · 189 citations

    3

    h-index

  4. Phytopathology

    3 publications · 101 citations

    3

    h-index

  5. PLoS ONE

    3 publications · 256 citations

    3

    h-index

1–5