Concepedia

Binding Pocket Remodeling

Binding Pocket Remodeling is a computational or experimental strategy within active site engineering that involves the structural redesign of an enzyme's substrate-binding cavity to alter its size, shape, polarity, or functional group composition in order to confer novel or enhanced substrate specificity, catalytic efficiency, or reaction selectivity.

21

Publications

864

Citations

113

Authors

43

Institutions

Publications per year

2017–2026

7

Parents

Publications

21

Structural analysis of the Sil1–Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor

Ming Yan, Jingzhi Li, Bingdong Sha · Biochemical Journal · 2011 · 71 citations

, , +14

Relocating a Negative Charge in the Binding Pocket of Trypsin

John J. Perona, Christopher Tsu, Mary E. McGrath et al. · Journal of Molecular Biology · 1993 · 70 citations

, , +8

NAD Binding Induces Conformational Changes in Rho ADP-ribosylating Clostridium botulinum C3 Exoenzyme

Julie Ménétrey, Gilles Flatau, E.A. Stura et al. · Journal of Biological Chemistry · 2002 · 68 citations · Full text

, , +17

Analysis of the crystal structure of an active MCM hexamer

Justin M. Miller, Buenafe T. Arachea, L.B. Epling et al. · eLife · 2014 · 65 citations · Full text

, , +14

Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors

Renato Ferreira de Freitas, Rachel Harding, Ivan Franzoni et al. · Journal of Medicinal Chemistry · 2018 · 63 citations · Full text

, , +14

1–5 of 21

Authors

113

  1. SK
    Sushil K. Mishra

    University of Mississippi, United States

    1 publications · 36 citations

    1

    h-index

  2. BD
    Bruce D. Dorsey

    United States Military Academy, United States

    1 publications · 42 citations

    1

    h-index

  3. DM
    David M. Clarke

    University of Toronto, Canada

    1 publications · 24 citations

    1

    h-index

  4. TR
    Triwit Rattanarojpong

    King Mongkut's University of Technology Thonburi, Thailand

    1 publications · 18 citations

    1

    h-index

  5. DF
    Dan-Ting Feng

    Jiangnan University, China

    1 publications · 18 citations

    1

    h-index

1–5 of 113

Institutions

43

  1. University of Toronto

    Toronto, Canada

    2 h-index

    13 publications

    702 citations

  2. Universidade do Porto

    Porto, Portugal

    1 h-index

    5 publications

    75 citations

  3. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    1 h-index

    7 publications

    476 citations

  4. Agency for Science, Technology and Research

    Singapore, Singapore

    1 h-index

    2 publications

    30 citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    1 h-index

    2 publications

    58 citations

  6. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    1 h-index

    7 publications

    119 citations

  7. Structural Genomics Consortium

    Toronto, Canada

    1 h-index

    8 publications

    504 citations

  8. Masaryk University

    Brno, Czechia

    1 h-index

    4 publications

    144 citations

1–8 of 43

Venues

  1. Journal of Biological Chemistry

    JBC · 2 publications · 120 citations

    2

    h-index

  2. Nature Communications

    1 publications · 17 citations

    1

    h-index

  3. Journal of Medicinal Chemistry

    1 publications · 63 citations

    1

    h-index

  4. eLife

    1 publications · 65 citations

    1

    h-index

  5. Journal of Molecular Biology

    JMB · 1 publications · 70 citations

    1

    h-index

1–5