Concepedia

Backbone Diversity

Backbone Diversity is a structural design principle in diversity-oriented synthesis that prioritizes variation in the core molecular framework of compounds to maximize scaffold diversity, distinguishing it from strategies focused on peripheral substituent diversity.

19

Publications

4.7K

Citations

87

Authors

44

Institutions

Publications per year

2017–2026

3

Parents

Publications

19

Multicomponent Reactions with Isocyanides

Alexander Dömlingꝉ, Ivar Ugi · Angewandte Chemie International Edition · 2000 · 4K citations

, , +14

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

Andrew T. Bockus, Katrina W. Lexa, Cameron R. Pye et al. · Journal of Medicinal Chemistry · 2015 · 136 citations

, , +17

A DNA‐Encoded Chemical Library Incorporating Elements of Natural Macrocycles

Cedric Stress, Basilius Sauter, Lukas Schneider et al. · Angewandte Chemie International Edition · 2019 · 97 citations · Full text

, , +17

Expanding the Scope of PNA‐Encoded Synthesis (PES): Mtt‐Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity‐Generating Reactions

Dalila Chouikhi, Mihai Ciobanu, Claudio Zambaldo et al. · Chemistry - A European Journal · 2012 · 72 citations

, , +15

Increasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic Core

Grant S. Murphy, Jeffrey Mills, Michael J. Miley et al. · Structure · 2012 · 65 citations · Full text

, , +16

1–5 of 19

Authors

87

  1. RS
    R. Scott Lokey

    University of California, Santa Cruz, United States

    2 publications · 153 citations

    2

    h-index

  2. RK
    Richard Karlsson

    University of Copenhagen, Denmark

    1 publications · 27 citations

    1

    h-index

  3. MG
    Márkó Grabarics

    Fritz Haber Institute of the Max Planck Society, Germany

    1 publications · 27 citations

    1

    h-index

  4. KC
    Kathryn C. R. Hund

    University of California, San Francisco, United States

    1 publications · 136 citations

    1

    h-index

  5. JE
    Jeremy E. Turnbull

    University of Liverpool, United Kingdom

    1 publications · 27 citations

    1

    h-index

1–5 of 87

Institutions

44

  1. University of California, Santa Cruz

    Santa Cruz, United States

    2 h-index

    10 publications

    1.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    7 publications

    444 citations

  3. University at Buffalo, State University of New York

    Buffalo, United States

    1 h-index

    2 publications

    130 citations

  4. Universidade de Vigo

    Vigo, Spain

    1 h-index

    1 publications

    12 citations

  5. University of Basel

    Basel, Switzerland

    1 h-index

    5 publications

    485 citations

  6. Wageningen University & Research

    Wageningen, The Netherlands

    1 h-index

    1 publications

    29 citations

  7. Utrecht University

    Utrecht, The Netherlands

    1 h-index

    1 publications

    27 citations

  8. MorphoSys (Germany)

    Planegg, Germany

    1 h-index

    1 publications

    4K citations

1–8 of 44

Venues

  1. Angewandte Chemie International Edition

    2 publications · 4.1K citations

    2

    h-index

  2. Tetrahedron

    2 publications · 29 citations

    2

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    2 publications · 30 citations

    2

    h-index

  4. Carbohydrate Research

    1 publications · 23 citations

    1

    h-index

  5. Journal of Medicinal Chemistry

    1 publications · 136 citations

    1

    h-index

1–5