Concepedia

Backbone Analogs

Backbone Analogs is a chemical construct in which the molecular scaffold of a biomolecule is modified through substitution or alteration of its native backbone atoms or linkages while preserving functional group orientation and overall topology, enabling enhanced stability, bioavailability, or functional diversification compared to natural backbones.

23

Publications

1.7K

Citations

92

Authors

34

Institutions

Publications per year

2017–2026

7

Variants

Backbone Analogues

Parents

Publications

23

Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backbone

Ole Buchardt, Peter E. Nielsen, Rolf H. Berg · Journal of the American Chemical Society · 1992 · 736 citations

, , +12

Backbone stability of quaternized polyaromatics for alkaline membrane fuel cells

Cy Fujimoto, Dae-Sik Kim, Michael Hibbs et al. · Journal of Membrane Science · 2012 · 311 citations

, , +16

Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration

Kelly L. George, W. Seth Horne · Accounts of Chemical Research · 2018 · 80 citations

, , +15

Synthesis and Biological Activity of NK-1 Selective, N-Backbone Cyclic Analogs of the C-Terminal Hexapeptide of Substance P

Gérardo Byk, David Halle, Irena Zeltser et al. · Journal of Medicinal Chemistry · 1996 · 58 citations · Full text

, , +17

Comblike, Monodisperse Polypeptoid Drag-Tags for DNA Separations by End-Labeled Free-Solution Electrophoresis (ELFSE)

Russell D. Haynes, Robert J. Meagher, Jong‐In Won et al. · Bioconjugate Chemistry · 2005 · 45 citations

, , +13

1–5 of 23

Authors

92

  1. CG
    Chaim Gilon

    Hebrew University of Jerusalem, Israel

    2 publications · 96 citations

    2

    h-index

  2. TJ
    Thomas J. Gardella

    Massachusetts General Hospital, United States

    2 publications · 75 citations

    2

    h-index

  3. WS
    W. Seth Horne

    University of Pittsburgh, United States

    2 publications · 91 citations

    2

    h-index

  4. SH
    Samuel H. Gellman

    University of Wisconsin–Madison, United States

    2 publications · 75 citations

    2

    h-index

  5. IZ
    Irena Zeltser

    Hebrew University of Jerusalem, Israel

    2 publications · 96 citations

    2

    h-index

1–5 of 92

Institutions

34

  1. University of Pittsburgh

    Pittsburgh, United States

    3 h-index

    7 publications

    287 citations

  2. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    4 publications

    150 citations

  3. Massachusetts General Hospital

    Boston, United States

    2 h-index

    4 publications

    155 citations

  4. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    4 publications

    48 citations

  5. Northwestern University

    Evanston, United States

    1 h-index

    5 publications

    225 citations

  6. Centre for Sustainable Energy

    Bristol, United Kingdom

    1 h-index

    1 publications

    736 citations

  7. University of Prince Edward Island

    Charlottetown, Canada

    1 h-index

    5 publications

    80 citations

  8. Dalhousie University

    Halifax, Canada

    1 h-index

    3 publications

    48 citations

1–8 of 34

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 127 citations

    3

    h-index

  2. Journal of the American Chemical Society

    JACS · 3 publications · 811 citations

    3

    h-index

  3. Accounts of Chemical Research

    2 publications · 114 citations

    2

    h-index

  4. Scientific Reports

    2 publications · 55 citations

    2

    h-index

  5. Journal of Applied Polymer Science

    1 publications · 10 citations

    1

    h-index

1–5