Concepedia

B Cell Negative Selection

B Cell Negative Selection is a biological process in immune system development whereby immature B cells exhibiting high-affinity receptors for self-antigens are selectively eliminated or functionally inactivated to prevent autoimmunity.

67

Publications

7K

Citations

393

Authors

137

Institutions

Publications per year

2017–2026

3

Parents

Publications

67

TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease

Jane A. Gross, Stacey R. Dillon, Sherri Mudri et al. · Immunity · 2001 · 622 citations · Full text

, , +16

Positive Selection of Natural Autoreactive B Cells

Kyoko Hayakawa, Masanao Asano, Susan A. Shinton et al. · Science · 1999 · 570 citations

, , +14

Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF

Robin Lesley, Ying Xu, Susan L. Kalled et al. · Immunity · 2004 · 567 citations · Full text

, , +14

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

Jason G. Cyster, Suzanne B. Hartley, Christopher C. Goodnow · Nature · 1994 · 541 citations

, , +14

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

Jason G. Cyster, Christopher C. Goodnow · Immunity · 1995 · 395 citations · Full text

, , +17

1–5 of 67

Authors

393

  1. JG
    John G. Monroe

    University of Pennsylvania, United States

    5 publications · 591 citations

    5

    h-index

  2. BD
    Betty Diamond

    Feinstein Institute for Medical Research, United States

    3 publications · 213 citations

    3

    h-index

  3. TG
    Thomas G. Graeber

    University of California, Los Angeles, United States

    3 publications · 391 citations

    3

    h-index

  4. JG
    Jason G. Cyster

    University of California, San Francisco, United States

    3 publications · 1.5K citations

    3

    h-index

  5. HG
    Huimin Geng

    University of California, San Francisco, United States

    3 publications · 391 citations

    3

    h-index

1–5 of 393

Institutions

137

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    15 publications

    3.8K citations

  2. University of Pennsylvania

    Philadelphia, United States

    8 h-index

    17 publications

    1.8K citations

  3. University of California, San Francisco

    San Francisco, United States

    5 h-index

    35 publications

    5.9K citations

  4. Cornell University

    Ithaca, United States

    5 h-index

    9 publications

    1.3K citations

  5. Harvard University

    Cambridge, United States

    5 h-index

    7 publications

    287 citations

  6. University of California, Los Angeles

    Los Angeles, United States

    4 h-index

    6 publications

    673 citations

  7. University of Chicago

    Chicago, United States

    3 h-index

    5 publications

    241 citations

  8. Technion – Israel Institute of Technology

    Haifa, Israel

    3 h-index

    9 publications

    223 citations

1–8 of 137

Venues

  1. The Journal of Immunology

    JI · 17 publications · 952 citations

    16

    h-index

  2. European Journal of Immunology

    EJI · 9 publications · 466 citations

    9

    h-index

  3. Immunity

    7 publications · 2.1K citations

    7

    h-index

  4. The Journal of Experimental Medicine

    6 publications · 821 citations

    6

    h-index

  5. Nature

    2 publications · 695 citations

    2

    h-index

1–5