Concepedia

B Cell Affinity Selection

B Cell Affinity Selection is a biological process in adaptive immune responses whereby B cells with membrane-bound antibodies exhibiting higher affinity for the presented antigen are preferentially selected for clonal expansion and differentiation during germinal center reactions.

215

Publications

20.8K

Citations

1.2K

Authors

351

Institutions

Publications per year

2017–2026

75

Parents

Publications

215

Imaging of Germinal Center Selection Events During Affinity Maturation

Christopher D.C. Allen, Takaharu Okada, Hao Tang et al. · Science · 2006 · 770 citations

, , +17

Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF

Robin Lesley, Ying Xu, Susan L. Kalled et al. · Immunity · 2004 · 567 citations · Full text

, , +14

Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

Didrik Paus, Tri Giang Phan, Tyani D. Chan et al. · The Journal of Experimental Medicine · 2006 · 541 citations · Full text

, , +17

Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate

Facundo D. Batista, Michael S. Neuberger · Immunity · 1998 · 500 citations · Full text

, , +13

Visualizing antibody affinity maturation in germinal centers

Jeroen M. J. Tas, Luka Mesin, Giulia Pasqual et al. · Science · 2016 · 494 citations · Full text

, , +17

1–5 of 215

Authors

1.2K

  1. MM
    Michael Meyer‐Hermann

    Helmholtz Centre for Infection Research, Germany

    17 publications · 1.5K citations

    14

    h-index

  2. GD
    Gabriel D. Victora

    Rockefeller University, United States

    13 publications · 2.2K citations

    12

    h-index

  3. GK
    Garnett Kelsoe

    Duke University, United States

    9 publications · 1.7K citations

    9

    h-index

  4. MC
    Michel C. Nussenzweig

    Rockefeller University, United States

    9 publications · 1.9K citations

    9

    h-index

  5. LM
    Luka Mesin

    Rockefeller University, United States

    8 publications · 1.2K citations

    8

    h-index

1–5 of 1.2K

Institutions

351

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    19 h-index

    74 publications

    18.9K citations

  2. Rockefeller University

    New York, United States

    16 h-index

    104 publications

    15.8K citations

  3. Harvard University

    Cambridge, United States

    15 h-index

    55 publications

    4.9K citations

  4. Helmholtz Centre for Infection Research

    Braunschweig, Germany

    13 h-index

    26 publications

    1.8K citations

  5. Technische Universität Braunschweig

    Braunschweig, Germany

    12 h-index

    14 publications

    1.4K citations

  6. University of California, San Francisco

    San Francisco, United States

    11 h-index

    42 publications

    10.7K citations

  7. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    10 h-index

    34 publications

    3.2K citations

  8. Yale University

    New Haven, United States

    10 h-index

    28 publications

    4.8K citations

1–8 of 351

Venues

  1. The Journal of Experimental Medicine

    33 publications · 5.6K citations

    29

    h-index

  2. The Journal of Immunology

    JI · 37 publications · 1.9K citations

    24

    h-index

  3. Science

    12 publications · 3.5K citations

    12

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 412 citations

    10

    h-index

  5. European Journal of Immunology

    EJI · 9 publications · 353 citations

    9

    h-index

1–5