Concepedia

Autoactivation Mechanisms

Autoactivation Mechanisms is a biochemical process whereby procaspases undergo self-cleavage or self-oligomerization to initiate their catalytic activity without requiring external proteolytic triggers, distinguishing it from activation pathways dependent on upstream enzymes or adaptor-mediated cleavage.

143

Publications

11.7K

Citations

698

Authors

251

Institutions

Publications per year

2017–2026

16

Parents

Publications

143

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

Srinivasa M. Srinivasula, Manzoor Ahmad, Teresa Fernandes‐Alnemri et al. · Molecular Cell · 1998 · 1.1K citations · Full text

, , +12

Structure–function analysis of the NB-ARC domain of plant disease resistance proteins

Gerben van Ooijen, Gabriele Mayr, Mobien Kasiem et al. · Journal of Experimental Botany · 2008 · 487 citations · Full text

, , +17

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

Stephen J. Weiss, Gary J. Peppin, X. Ortiz et al. · Science · 1985 · 469 citations

, , +17

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Jennifer M. Golas, Kim Arndt, Carlo Etienne et al. · PubMed · 2003 · 414 citations

, , +17

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

Teresa Fernandes‐Alnemri, Atsushi Takahashi, Robert Armstrong et al. · PubMed · 1995 · 394 citations

, , +15

1–5 of 143

Authors

698

  1. MS
    Miklós Sahin‐Tóth

    Boston University, United States

    10 publications · 723 citations

    9

    h-index

  2. WK
    Walter Kisiel

    University of New Mexico, United States

    3 publications · 221 citations

    3

    h-index

  3. ZW
    Zhi‐Xin Wang

    Tsinghua University, China

    3 publications · 101 citations

    3

    h-index

  4. IS
    Inger Schousboe

    University of Copenhagen, Denmark

    3 publications · 92 citations

    3

    h-index

  5. GD
    G.F. De Nicola

    King's College London, United Kingdom

    2 publications · 51 citations

    2

    h-index

1–5 of 698

Institutions

251

  1. University of Michigan

    Ann Arbor, United States

    6 h-index

    19 publications

    2.9K citations

  2. Boston University

    Boston, United States

    6 h-index

    12 publications

    440 citations

  3. Inserm

    Paris, France

    4 h-index

    14 publications

    840 citations

  4. University of Oxford

    Oxford, United Kingdom

    4 h-index

    6 publications

    800 citations

  5. University of California, Los Angeles

    Los Angeles, United States

    4 h-index

    8 publications

    628 citations

  6. Aarhus University

    Aarhus, Denmark

    3 h-index

    13 publications

    1.3K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    13 publications

    339 citations

  8. Institute of Biophysics

    Beijing, China

    3 h-index

    4 publications

    127 citations

1–8 of 251

Venues

  1. Journal of Biological Chemistry

    JBC · 37 publications · 2.8K citations

    30

    h-index

  2. Molecular and Cellular Biology

    MCB · 9 publications · 572 citations

    9

    h-index

  3. PubMed

    Repository · 9 publications · 1.1K citations

    9

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 612 citations

    6

    h-index

  5. Biochemical Journal

    BJ · 5 publications · 502 citations

    5

    h-index

1–5