Concepedia

Atr-mediated Replication Control

ATR-Mediated Replication Control is a regulatory mechanism in DNA replication that belongs to the class of checkpoint signaling pathways, distinguished by its specific activation of the ATR kinase in response to replication stress to stabilize stalled replication forks and suppress origin firing.

93

Publications

9K

Citations

771

Authors

251

Institutions

Publications per year

2017–2026

41

Parents

Publications

93

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

Luis Toledo, Matthias Altmeyer, Maj‐Britt Rask et al. · Cell · 2013 · 939 citations · Full text

, , +13

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Tony Byun, Marcin Pacek, Muh‐Ching Yee et al. · Genes & Development · 2005 · 757 citations · Full text

, , +17

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in <i>Xenopus</i> egg extracts

Zijian Guo, Akiko Kumagai, Sophie X. Wang et al. · Genes & Development · 2000 · 408 citations · Full text

, , +17

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

Vincenzo Costanzo, David Shechter, Patrick J. Lupardus et al. · Molecular Cell · 2003 · 344 citations · Full text

, , +16

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Rémi Buisson, Jessica L. Boisvert, Cyril H. Benes et al. · Molecular Cell · 2015 · 310 citations · Full text

, , +16

1–5 of 93

Authors

771

  1. KA
    Karlene A. Cimprich

    Stanford University, United States

    6 publications · 1.5K citations

    6

    h-index

  2. WG
    William G. Dunphy

    California Institute of Technology, United States

    5 publications · 761 citations

    5

    h-index

  3. JB
    Jiří Bártek

    Danish Cancer Society, Denmark

    4 publications · 1.2K citations

    4

    h-index

  4. NM
    Niels Mailand

    Novo Nordisk Foundation, Denmark

    4 publications · 1.1K citations

    4

    h-index

  5. LZ
    Lee Zou

    Massachusetts General Hospital, United States

    3 publications · 476 citations

    3

    h-index

1–5 of 771

Institutions

251

  1. Stanford University

    Stanford, United States

    7 h-index

    31 publications

    6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    33 publications

    3.5K citations

  3. Institut de Génétique Humaine

    Montpellier, France

    6 h-index

    18 publications

    2.5K citations

  4. California Institute of Technology

    Pasadena, United States

    5 h-index

    14 publications

    2.6K citations

  5. Novo Nordisk Foundation

    Copenhagen, Denmark

    4 h-index

    23 publications

    9.2K citations

  6. University of Copenhagen

    Copenhagen, Denmark

    4 h-index

    31 publications

    9.7K citations

  7. Massachusetts General Hospital

    Boston, United States

    4 h-index

    10 publications

    2K citations

  8. Harvard University

    Cambridge, United States

    4 h-index

    9 publications

    2.9K citations

1–8 of 251

Venues

  1. Nature Communications

    9 publications · 692 citations

    9

    h-index

  2. Molecular Cell

    8 publications · 1.5K citations

    8

    h-index

  3. Nucleic Acids Research

    6 publications · 273 citations

    6

    h-index

  4. Journal of Biological Chemistry

    JBC · 6 publications · 373 citations

    6

    h-index

  5. Journal of Virology

    JVI · 5 publications · 279 citations

    5

    h-index

1–5