Concepedia

Astrocyte Complement Activation

Astrocyte Complement Activation is a molecular pathway in which astrocytes initiate and regulate components of the complement system, distinguishing it as a glial-driven mechanism within neuroimmune surveillance that modulates synaptic pruning and inflammatory responses in the central nervous system.

161

Publications

11.3K

Citations

836

Authors

316

Institutions

Publications per year

2017–2026

70

Parents

Publications

161

Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis

Shanu F. Roemer, Joseph E. Parisi, Vanda A. Lennon et al. · Brain · 2007 · 714 citations · Full text

, , +17

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Hong Lian, Alexandra Litvinchuk, Angie C.A. Chiang et al. · Journal of Neuroscience · 2016 · 600 citations · Full text

, , +17

High complement levels in astrocyte‐derived exosomes of Alzheimer disease

Edward J. Goetzl, Janice B. Schwartz, Erin L. Abner et al. · Annals of Neurology · 2018 · 385 citations

, , +17

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

Shannon R. Hinson, Shanu F. Roemer, Claudia F. Lucchinetti et al. · The Journal of Experimental Medicine · 2008 · 350 citations · Full text

, , +17

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines.

Philippe Gasque, Michele Fontaine, B. Paul Morgan · The Journal of Immunology · 1995 · 238 citations

, , +15

1–5 of 161

Authors

836

  1. BP
    B. Paul Morgan

    Cardiff University, United Kingdom

    12 publications · 1.3K citations

    12

    h-index

  2. PG
    Philippe Gasque

    University of Wales, United Kingdom

    11 publications · 1.3K citations

    11

    h-index

  3. MF
    Marc Fontaine

    Inserm, France

    11 publications · 1.1K citations

    11

    h-index

  4. AS
    A. S. Verkman

    University of California, San Francisco, United States

    9 publications · 420 citations

    9

    h-index

  5. SR
    Scott R. Barnum

    University of Alabama at Birmingham, United States

    7 publications · 505 citations

    7

    h-index

1–5 of 836

Institutions

316

  1. University of California, San Francisco

    San Francisco, United States

    14 h-index

    31 publications

    2.4K citations

  2. University of Wales

    Cardiff, United Kingdom

    11 h-index

    31 publications

    3.2K citations

  3. Inserm

    Paris, France

    11 h-index

    39 publications

    2.7K citations

  4. University of Alabama at Birmingham

    Birmingham, United States

    7 h-index

    15 publications

    1.3K citations

  5. Mayo Clinic

    Rochester, United States

    6 h-index

    33 publications

    11.2K citations

  6. State Research Institute of Highly Pure Biopreparations

    Saint Petersburg, Russia

    5 h-index

    5 publications

    335 citations

  7. The University of Queensland

    Brisbane, Australia

    5 h-index

    8 publications

    1K citations

  8. Shaanxi Normal University

    Xi'an, China

    4 h-index

    7 publications

    227 citations

1–8 of 316

Venues

  1. The Journal of Immunology

    JI · 12 publications · 1.6K citations

    12

    h-index

  2. Journal of Neuroinflammation

    JNI · 8 publications · 339 citations

    8

    h-index

  3. Glia

    7 publications · 581 citations

    7

    h-index

  4. Brain

    5 publications · 916 citations

    5

    h-index

  5. Acta Neuropathologica Communications

    4 publications · 213 citations

    4

    h-index

1–5