Concepedia

Assembly Line Biosynthesis

Assembly Line Biosynthesis is a biosynthetic mechanism in which modular enzymatic complexes sequentially activate, modify, and incorporate monomeric building blocks into a growing peptide chain through coordinated, repetitive catalytic cycles, each catalyzed by a distinct enzymatic domain within a multimodular synthetase.

74

Publications

3.7K

Citations

381

Authors

122

Institutions

Publications per year

2017–2026

35

Parents

Publications

74

Distribution of Saccharide Residues on Membrane Fragments from a Myeloma-Cell Homogenate: Its Implications for Membrane Biogenesis

Hiroshi Hirano, Brenda Parkhouse, Garth L. Nicolson et al. · Proceedings of the National Academy of Sciences · 1972 · 182 citations · Full text

, , +13

Fungal cell wall synthesis: the construction of a biological structure.

E Cabib, Blair Bowers, Adriana Sburlati et al. · PubMed · 1988 · 169 citations

, , +17

Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility

Janice M. Reimer, Maximilian Eivaskhani, I. Harb et al. · Science · 2019 · 134 citations · Full text

, , +17

Quantitative Analysis of the Relative Contributions of Donor Acyl Carrier Proteins, Acceptor Ketosynthases, and Linker Regions to Intermodular Transfer of Intermediates in Hybrid Polyketide Synthases

Nicholas Wu, David E. Cane, Chaitan Khosla · Biochemistry · 2002 · 130 citations

, , +15

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation

Shiven Kapur, Brian Lowry, Satoshi Yuzawa et al. · Proceedings of the National Academy of Sciences · 2012 · 110 citations · Full text

, , +17

1–5 of 74

Authors

381

  1. CT
    Christopher T. Walsh

    Harvard University, United States

    12 publications · 564 citations

    12

    h-index

  2. CK
    Chaitan Khosla

    Stanford University, United States

    6 publications · 437 citations

    6

    h-index

  3. NL
    Neil L. Kelleher

    Northwestern University, United States

    6 publications · 362 citations

    6

    h-index

  4. NA
    Nathan A. Magarvey

    McMaster University, Canada

    6 publications · 254 citations

    6

    h-index

  5. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    4 publications · 215 citations

    4

    h-index

1–5 of 381

Institutions

122

  1. Harvard University

    Cambridge, United States

    15 h-index

    54 publications

    2.9K citations

  2. Stanford University

    Stanford, United States

    6 h-index

    34 publications

    2.2K citations

  3. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    13 publications

    289 citations

  4. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    16 publications

    815 citations

  5. Scripps Institution of Oceanography

    La Jolla, United States

    4 h-index

    11 publications

    581 citations

  6. University of Illinois Urbana-Champaign

    Urbana, United States

    4 h-index

    10 publications

    558 citations

  7. Shanghai Institute of Organic Chemistry

    Shanghai, China

    4 h-index

    16 publications

    371 citations

  8. McMaster University

    Hamilton, Canada

    4 h-index

    16 publications

    555 citations

1–8 of 122

Venues

  1. Journal of the American Chemical Society

    JACS · 15 publications · 786 citations

    14

    h-index

  2. ACS Chemical Biology

    8 publications · 298 citations

    8

    h-index

  3. Nature Communications

    7 publications · 365 citations

    7

    h-index

  4. Angewandte Chemie International Edition

    6 publications · 148 citations

    6

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 481 citations

    5

    h-index

1–5