Concepedia

Arene Oxides

Arene Oxide is a reactive metabolic intermediate formed by the epoxidation of aromatic rings, distinguished from other xenobiotic metabolites by its strained three-membered epoxide structure that facilitates electrophilic attack on cellular macromolecules.

219

Publications

12.2K

Citations

589

Authors

141

Institutions

Publications per year

2017–2026

7

Variants

Arene Epoxides

Parents

Publications

219

Arene Oxides: A New Aspect of Drug Metabolism

D. M. JERINA, John W. Daly · Science · 1974 · 1K citations

, , +14

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

John W. Daly, D. M. JERINA, Bernhard Witkop · Cellular and Molecular Life Sciences · 1972 · 599 citations

, , +10

Anticonvulsant Hypersensitivity Syndrome

Carmela C. Vittorio · Archives of Internal Medicine · 1995 · 423 citations

, , +15

Intramolecular Reactions of Alkynes with Furans and Electron Rich Arenes Catalyzed by PtCl<sub>2</sub>:  The Role of Platinum Carbenes as Intermediates

Belén Martín‐Matute, Cristina Nevado, Diego J. Cárdenas et al. · Journal of the American Chemical Society · 2003 · 266 citations

, , +16

Predisposition to Phenytoin Hepatotoxicity Assessed in Vitro

Stephen P. Spielberg, Gary Gordon, David A. Blake et al. · New England Journal of Medicine · 1981 · 236 citations

, , +15

1–5 of 219

Authors

589

  1. DM
    Donald M. Jerina

    National Institutes of Health, United States

    26 publications · 1.3K citations

    19

    h-index

  2. DM
    D. M. JERINA

    National Institutes of Health, United States

    19 publications · 2.9K citations

    19

    h-index

  3. WL
    Wayne Levin

    La Roche College, United States

    18 publications · 1.2K citations

    18

    h-index

  4. DR
    Derek R. Boyd

    Queen's University Belfast, United Kingdom

    24 publications · 556 citations

    17

    h-index

  5. HY
    Haruhiko Yagi

    National Institutes of Health, United States

    15 publications · 863 citations

    15

    h-index

1–5 of 589

Institutions

141

  1. National Institutes of Health

    Bethesda, United States

    17 h-index

    53 publications

    7.1K citations

  2. National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Bethesda, United States

    12 h-index

    35 publications

    6.4K citations

  3. Queen's University Belfast

    Belfast, United Kingdom

    9 h-index

    51 publications

    1.2K citations

  4. La Roche College

    Pittsburgh, United States

    6 h-index

    19 publications

    1K citations

  5. University of Stuttgart

    Stuttgart, Germany

    4 h-index

    14 publications

    1.9K citations

  6. May Institute

    Randolph, United States

    4 h-index

    7 publications

    236 citations

  7. University of New Orleans

    New Orleans, United States

    4 h-index

    12 publications

    244 citations

  8. National Center for Toxicological Research

    Pine Bluff, United States

    4 h-index

    15 publications

    513 citations

1–8 of 141

Venues

  1. Journal of the American Chemical Society

    JACS · 36 publications · 2.4K citations

    25

    h-index

  2. Tetrahedron Letters

    12 publications · 310 citations

    12

    h-index

  3. PubMed

    Repository · 14 publications · 563 citations

    12

    h-index

  4. The Journal of Organic Chemistry

    JOC · 10 publications · 225 citations

    10

    h-index

  5. Journal of Biological Chemistry

    JBC · 9 publications · 618 citations

    9

    h-index

1–5