Concepedia

Arc-mediated Synaptic Scaling

Arc-Mediated Synaptic Scaling is a molecular mechanism of homeostatic synaptic plasticity in which the activity-regulated cytoskeleton-associated protein (Arc) mediates the cell-wide downscaling of synaptic strength by facilitating the internalization of AMPA receptors in response to elevated neuronal activity.

9

Publications

1.4K

Citations

37

Authors

23

Institutions

Publications per year

2017–2026

2

Parents

Publications

9

Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors

Jason D. Shepherd, Gavin Rumbaugh, Jing Wu et al. · Neuron · 2006 · 795 citations · Full text

, , +14

Arc-dependent synapse-specific homeostatic plasticity

Jean-Claude Béïque, Youn Na, Dietmar Kuhl et al. · Proceedings of the National Academy of Sciences · 2010 · 184 citations · Full text

, , +17

A Specific Requirement of Arc/Arg3.1 for Visual Experience-Induced Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex

Ming Gao, Kenneth G. Sossa, Lihua Song et al. · Journal of Neuroscience · 2010 · 149 citations · Full text

, , +17

Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2

Luis L. P. daSilva, Mark J. Wall, Luciana Previato de Almeida et al. · eNeuro · 2016 · 88 citations · Full text

, , +17

Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation

Tim J. Craig, Nadia Jaafari, Miloš Petrović et al. · Journal of Biological Chemistry · 2012 · 79 citations · Full text

, , +17

1–5 of 9

Authors

37

  1. DK
    Dietmar Kuhl

    Universität Hamburg, Germany

    3 publications · 1.1K citations

    3

    h-index

  2. PF
    Paul F. Worley

    Johns Hopkins University, United States

    3 publications · 1.1K citations

    3

    h-index

  3. JM
    Jeremy M. Henley

    University of Bristol, United Kingdom

    2 publications · 90 citations

    2

    h-index

  4. JD
    Jason D. Shepherd

    University of Utah, United States

    2 publications · 853 citations

    2

    h-index

  5. TJ
    Tim J. Craig

    University of Bristol, United Kingdom

    2 publications · 90 citations

    2

    h-index

1–5 of 37

Institutions

23

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    8 publications

    3.1K citations

  2. Johns Hopkins University

    Baltimore, United States

    3 h-index

    8 publications

    5.1K citations

  3. Johns Hopkins Medicine

    Baltimore, United States

    3 h-index

    8 publications

    5.1K citations

  4. Medical Research Council

    London, United Kingdom

    2 h-index

    4 publications

    248 citations

  5. Universität Hamburg

    Hamburg, Germany

    2 h-index

    3 publications

    517 citations

  6. University of Bristol

    Bristol, United Kingdom

    2 h-index

    8 publications

    496 citations

  7. University Medical Center Hamburg-Eppendorf

    Hamburg, Germany

    2 h-index

    3 publications

    517 citations

  8. H. L. Snyder Medical Foundation

    Winfield, United States

    1 h-index

    4 publications

    736 citations

1–8 of 23

Venues

  1. Frontiers in Molecular Neuroscience

    2 publications · 115 citations

    2

    h-index

  2. Journal of Biological Chemistry

    JBC · 1 publications · 79 citations

    1

    h-index

  3. Journal of Neuroscience

    1 publications · 149 citations

    1

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 184 citations

    1

    h-index

  5. Communicative & Integrative Biology

    1 publications · 11 citations

    1

    h-index

1–5