Concepedia

Aptazyme Engineering

Aptazyme Engineering is a methodological framework within RNA circuit design that integrates allosteric ribozymes with aptamers to enable ligand-dependent modulation of RNA structure and function, distinguishing it from other RNA engineering approaches by its reliance on conformational switching triggered by specific molecular binding events.

25

Publications

1.5K

Citations

77

Authors

28

Institutions

Publications per year

2017–2026

8

Parents

Publications

25

Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

Weixin Tang, Johnny H. Hu, David R. Liu · Nature Communications · 2017 · 226 citations · Full text

, , +17

Using a Deoxyribozyme Ligase and Rolling Circle Amplification To Detect a Non-nucleic Acid Analyte, ATP

Eun Jeong Cho, Litao Yang, Matthew Levy et al. · Journal of the American Chemical Society · 2005 · 197 citations

, , +17

Model-Driven Engineering of RNA Devices to Quantitatively Program Gene Expression

James M. Carothers, Jonathan A. Goler, Darmawi Juminaga et al. · Science · 2011 · 185 citations

, , +17

Improved Aptazyme Design and In Vivo Screening Enable Riboswitching in Bacteria

Markus Wieland, Jörg S. Hartig · Angewandte Chemie International Edition · 2008 · 184 citations

, , +14

Group I aptazymes as genetic regulatory switches

Kristin Thompson, Heather A. Syrett, Scott M. Knudsen et al. · BMC Biotechnology · 2002 · 92 citations · Full text

, , +14

1–5 of 25

Authors

77

  1. AD
    Andrew D. Ellington

    The University of Texas at Austin, United States

    5 publications · 450 citations

    5

    h-index

  2. JS
    Jörg S. Hartig

    University of Konstanz, Germany

    5 publications · 279 citations

    5

    h-index

  3. YY
    Yohei Yokobayashi

    Okinawa Institute of Science and Technology Graduate University, Japan

    2 publications · 94 citations

    2

    h-index

  4. MW
    Markus Wieland

    University of Konstanz, Germany

    2 publications · 222 citations

    2

    h-index

  5. AO
    Atsushi Ogawa

    Ehime University, Japan

    2 publications · 66 citations

    2

    h-index

1–5 of 77

Institutions

28

  1. The University of Texas at Austin

    Austin, United States

    5 h-index

    12 publications

    1.4K citations

  2. University of Konstanz

    Konstanz, Germany

    5 h-index

    14 publications

    673 citations

  3. Zhengzhou University

    Zhengzhou, China

    1 h-index

    6 publications

    186 citations

  4. University of California, Berkeley

    Berkeley, United States

    1 h-index

    2 publications

    370 citations

  5. University of Bonn

    Bonn, Germany

    1 h-index

    1 publications

    54 citations

  6. Broad Institute

    Cambridge, United States

    1 h-index

    3 publications

    678 citations

  7. University of California, Santa Cruz

    Santa Cruz, United States

    1 h-index

    1 publications

    52 citations

  8. Northwestern University

    Evanston, United States

    1 h-index

    1 publications

    13 citations

1–8 of 28

Venues

  1. Methods in molecular biology

    Book series · 2 publications · 25 citations

    2

    h-index

  2. Chemical Communications

    ChemComm · 2 publications · 67 citations

    2

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    2 publications · 66 citations

    2

    h-index

  4. Chemistry & Biology

    1 publications · 38 citations

    1

    h-index

  5. PubMed

    Repository · 1 publications · 54 citations

    1

    h-index

1–5