Concepedia

Antigen Structure Optimization

Antigen Structure Optimization is a computational or experimental methodology that systematically refines the three-dimensional conformation and physicochemical properties of an antigen to enhance its immunogenicity, stability, and specificity for targeted immune recognition.

20

Publications

2K

Citations

154

Authors

60

Institutions

Publications per year

2017–2026

10

Parents

Publications

20

Structure-based programming of lymph-node targeting in molecular vaccines

Haipeng Liu, Kelly D. Moynihan, Yiran Zheng et al. · Nature · 2014 · 941 citations

, , +14

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

Ron Diskin, Johannes F. Scheid, Paola Marcovecchio et al. · Science · 2011 · 377 citations

, , +13

Multivalent Antigens for Promoting B and T Cell Activation

Nitasha R. Bennett, Daniel B. Zwick, Adam H. Courtney et al. · ACS Chemical Biology · 2015 · 92 citations · Full text

, , +17

Impact of scFv structure in chimeric antigen receptor on receptor expression efficiency and antigen recognition properties

Kento Fujiwara, Mizuki Masutani, Masashi Tachibana et al. · Biochemical and Biophysical Research Communications · 2020 · 81 citations

, , +17

Unconstrained generation of synthetic antibody–antigen structures to guide machine learning methodology for antibody specificity prediction

Philippe A. Robert, Rahmad Akbar, Robert Frank et al. · Nature Computational Science · 2022 · 56 citations

, , +14

1–5 of 20

Authors

154

  1. SR
    Spencer R. Pierce

    University of Georgia, United States

    2 publications · 40 citations

    2

    h-index

  2. JW
    Jeffrey W. Ecker

    University of Georgia, United States

    2 publications · 40 citations

    2

    h-index

  3. TM
    Ted M. Ross

    University of Georgia, United States

    2 publications · 40 citations

    2

    h-index

  4. JJ
    Jarrod J. Mousa

    University of Georgia, United States

    2 publications · 40 citations

    2

    h-index

  5. NY
    Noa Yeshaya

    Weizmann Institute of Science, Israel

    1 publications · 39 citations

    1

    h-index

1–5 of 154

Institutions

60

  1. University of Georgia

    Athens, United States

    2 h-index

    13 publications

    261 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    3 publications

    1.7K citations

  3. Scripps Research Institute

    San Diego, United States

    1 h-index

    2 publications

    38 citations

  4. Johannes Kepler University of Linz

    Linz, Austria

    1 h-index

    3 publications

    168 citations

  5. Bharathiar University

    Coimbatore, India

    1 h-index

    2 publications

    28 citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    1 h-index

    8 publications

    7.5K citations

  7. Institute for Bioscience and Biotechnology Research

    Rockville, United States

    1 h-index

    12 publications

    408 citations

  8. Griffith University

    Brisbane, Australia

    1 h-index

    3 publications

    48 citations

1–8 of 60

Venues

  1. PubMed

    Repository · 2 publications · 51 citations

    2

    h-index

  2. Vaccine

    2 publications · 37 citations

    2

    h-index

  3. Science

    1 publications · 377 citations

    1

    h-index

  4. Journal of Molecular Biology

    JMB · 1 publications · 34 citations

    1

    h-index

  5. Journal of Computer-Aided Molecular Design

    1 publications · 14 citations

    1

    h-index

1–5