Concepedia

Antigen Binding Affinity Optimization

Antigen Binding Affinity Optimization is a computational or experimental methodology designed to enhance the strength and specificity of interactions between an antibody and its target antigen through systematic modification of antibody structural features.

39

Publications

1.5K

Citations

244

Authors

90

Institutions

Publications per year

2017–2026

21

Parents

Publications

39

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization

Esther Drent, Maria Themeli, Renée Poels et al. · Molecular Therapy · 2017 · 288 citations · Full text

, , +17

Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding

Patrick Koenig, Chingwei V. Lee, Benjamin T. Walters et al. · Proceedings of the National Academy of Sciences · 2017 · 117 citations · Full text

, , +17

Design of bioactive peptides based on antibody hypervariable region structures. Development of conformationally constrained and dimeric peptides with enhanced affinity.

William V. Williams, Thomas Kieber‐Emmons, Joan M. VonFeldt et al. · Journal of Biological Chemistry · 1991 · 108 citations · Full text

, , +17

Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex

Masato Kiyoshi, José M. M. Caaveiro, Eri Miura‐Fujiwara et al. · PLoS ONE · 2014 · 99 citations · Full text

, , +17

Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration

Patrick Koenig, Chingwei V. Lee, Sarah Sanowar et al. · Journal of Biological Chemistry · 2015 · 63 citations · Full text

, , +17

1–5 of 39

Authors

244

  1. KT
    Kouhei Tsumoto

    The University of Tokyo, Japan

    3 publications · 154 citations

    3

    h-index

  2. PK
    Patrick Koenig

    Heidelberg University, Germany

    2 publications · 180 citations

    2

    h-index

  3. MN
    Makoto Nakakido

    The University of Tokyo, Japan

    2 publications · 142 citations

    2

    h-index

  4. JB
    Jason Baardsnes

    National Research Council Canada, Canada

    2 publications · 69 citations

    2

    h-index

  5. GF
    Germaine Fuh

    Genentech

    2 publications · 180 citations

    2

    h-index

1–5 of 244

Institutions

90

  1. The University of Tokyo

    Tokyo, Japan

    5 h-index

    26 publications

    1.2K citations

  2. Universidade de São Paulo

    São Paulo, Brazil

    2 h-index

    2 publications

    30 citations

  3. University of Cagliari

    Cagliari, Italy

    2 h-index

    3 publications

    48 citations

  4. North Carolina State University

    Raleigh, United States

    2 h-index

    2 publications

    30 citations

  5. Grigore T. Popa University of Medicine and Pharmacy

    Iasi, Romania

    2 h-index

    2 publications

    30 citations

  6. Luleå University of Technology

    Luleå, Sweden

    2 h-index

    2 publications

    30 citations

  7. Stockholm University

    Stockholm, Sweden

    2 h-index

    2 publications

    30 citations

  8. National Research Council Canada

    Ottawa, Canada

    2 h-index

    23 publications

    804 citations

1–8 of 90

Venues

  1. Protein Engineering Design and Selection

    PEDS · 3 publications · 60 citations

    3

    h-index

  2. PLoS ONE

    3 publications · 168 citations

    3

    h-index

  3. Journal of Biological Chemistry

    JBC · 3 publications · 211 citations

    3

    h-index

  4. Journal of Immunological Methods

    2 publications · 74 citations

    2

    h-index

  5. Scientific Reports

    1 publications · 39 citations

    1

    h-index

1–5