Concepedia

Allostery

Allostery is a regulatory mechanism in which the binding of a ligand at one site of a protein induces a conformational or dynamic change that alters the functional activity at a distinct, distant site within the same protein.

196

Publications

12.2K

Citations

937

Authors

372

Institutions

Publications per year

2017–2026

85

Parents

Publications

196

Allostery without conformational change

Alan Cooper, David T. F. Dryden · European Biophysics Journal · 1984 · 745 citations

, , +7

Cucurbit[n]urils: from mechanism to structure and function

Lyle Isaacs · Chemical Communications · 2008 · 427 citations

, , +13

A Unified View of “How Allostery Works”

Chung‐Jung Tsai, Ruth Nussinov · PLoS Computational Biology · 2014 · 415 citations · Full text

, , +13

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

Wendy R. Gordon, Brandon Zimmerman, Li He et al. · Developmental Cell · 2015 · 385 citations · Full text

, , +9

Structural basis for allosteric PARP-1 retention on DNA breaks

Levani Zandarashvili, Marie-France Langelier, Uday Kiran Velagapudi et al. · Science · 2020 · 331 citations · Full text

, , +17

1–5 of 196

Authors

937

  1. TM
    Tom McLeish

    University of Leeds, United Kingdom

    8 publications · 349 citations

    8

    h-index

  2. MV
    Michele Vendruscolo

    University of Cambridge, United Kingdom

    3 publications · 238 citations

    3

    h-index

  3. JZ
    Jian Zhang

    Shanghai Jiao Tong University, China

    3 publications · 295 citations

    3

    h-index

  4. JM
    John M. Pascal

    Université de Montréal, Canada

    3 publications · 624 citations

    3

    h-index

  5. GS
    Ganesh S. Anand

    National University of Singapore, Singapore

    3 publications · 72 citations

    3

    h-index

1–5 of 937

Institutions

372

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    12 publications

    1.4K citations

  2. University of Pennsylvania

    Philadelphia, United States

    7 h-index

    24 publications

    4.7K citations

  3. University of California San Diego

    San Diego, United States

    6 h-index

    16 publications

    1.1K citations

  4. University of Maryland, College Park

    College Park, United States

    5 h-index

    9 publications

    897 citations

  5. University of California, San Francisco

    San Francisco, United States

    5 h-index

    19 publications

    788 citations

  6. ETH Zurich

    Zurich, Switzerland

    5 h-index

    14 publications

    478 citations

  7. Columbia University

    New York, United States

    5 h-index

    13 publications

    1.4K citations

  8. Harvard University

    Cambridge, United States

    5 h-index

    26 publications

    5.1K citations

1–8 of 372

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 24 publications · 1.7K citations

    21

    h-index

  2. Journal of Molecular Biology

    JMB · 10 publications · 390 citations

    10

    h-index

  3. Structure

    8 publications · 523 citations

    8

    h-index

  4. Biophysical Journal

    8 publications · 260 citations

    8

    h-index

  5. Nature Communications

    8 publications · 615 citations

    8

    h-index

1–5