Concepedia

Allosteric Site Engineering

Allosteric Site Engineering is the rational design or modification of specific regulatory sites in a protein distinct from its active site, enabling controlled modulation of protein function through conformational changes induced by effector binding.

9

Publications

338

Citations

38

Authors

15

Institutions

Publications per year

2017–2026

2

Parents

Publications

9

A new allosteric site in glycogen phosphorylase b as a target for drug interactions

Nikos G. Oikonomakos, Katerina E. Tsitsanou, Nikos G. Gavalas et al. · Structure · 2000 · 132 citations · Full text

, , +16

Designing Allosteric Control into Enzymes by Chemical Rescue of Structure

Katelyn Deckert, S. Jimmy Budiardjo, Luke C. Brunner et al. · Journal of the American Chemical Society · 2012 · 56 citations

, , +17

Engineering allosteric regulation in protein kinases

David Pincus, Jai Prakash Pandey, Zoë A. Feder et al. · Science Signaling · 2018 · 36 citations · Full text

, , +14

The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in <i>Saccharomyces cerevisiae</i>

Héctor Quezada, Álvaro Marín‐Hernández, Diana Aguilar et al. · Molecular Microbiology · 2011 · 27 citations · Full text

, , +17

Rational design of allosteric-inhibition sites in classical protein tyrosine phosphatases

Cynthia M. Chio, Xiaoling Yu, Anthony C. Bishop · Bioorganic & Medicinal Chemistry · 2015 · 27 citations

, , +16

1–5 of 9

Authors

38

  1. NG
    Nikos G. Oikonomakos

    National Hellenic Research Foundation, Greece

    1 publications · 132 citations

    1

    h-index

  2. VM
    Valéry Mathieu

    UCLouvain, Belgium

    1 publications · 11 citations

    1

    h-index

  3. PC
    Pau Creixell

    Technical University of Denmark, Denmark

    1 publications · 36 citations

    1

    h-index

  4. KS
    K. S. Madhusoodanan

    Hospital Research Foundation, Australia

    1 publications · 13 citations

    1

    h-index

  5. RF
    Roberta F. Colman

    University of Delaware, United States

    1 publications · 13 citations

    1

    h-index

1–5 of 38

Institutions

15

  1. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    1 h-index

    2 publications

    54 citations

  2. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

    Mexico City, Mexico

    1 h-index

    1 publications

    27 citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    1 h-index

    4 publications

    144 citations

  4. University of Kansas

    Lawrence, United States

    1 h-index

    5 publications

    280 citations

  5. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    2 publications

    28 citations

  6. University of Delaware

    Newark, United States

    1 h-index

    2 publications

    26 citations

  7. UCLouvain

    Louvain-la-Neuve, Belgium

    1 h-index

    3 publications

    33 citations

  8. Whitehead Institute for Biomedical Research

    Cambridge, United States

    1 h-index

    3 publications

    108 citations

1–8 of 15

Venues

  1. Protein Engineering Design and Selection

    PEDS · 1 publications · 11 citations

    1

    h-index

  2. Journal of the American Chemical Society

    JACS · 1 publications · 56 citations

    1

    h-index

  3. Protein Science

    PS · 1 publications · 14 citations

    1

    h-index

  4. Biophysical Chemistry

    BPC · 1 publications · 22 citations

    1

    h-index

  5. Science Signaling

    1 publications · 36 citations

    1

    h-index

1–5