Concepedia

Allosteric Oligomerization

Allosteric Oligomerization is a regulatory mechanism in protein assembly whereby the binding of an effector molecule at one site induces conformational changes that modulate the oligomerization state or functional activity at a distant site within a multimeric protein complex.

10

Publications

557

Citations

65

Authors

21

Institutions

Publications per year

2017–2026

2

Parents

Publications

10

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

J.W. Fairman, Sanath R. Wijerathna, Shabbir Ahmad et al. · Nature Structural & Molecular Biology · 2011 · 176 citations · Full text

, , +16

An engineered allosteric switch in leucine-zipper oligomerization

Lino C. Gonzalez, Joseph J. Plecs, Tom Alber · Nature Structural & Molecular Biology · 1996 · 109 citations

, , +13

Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression

Sarah Meinhardt, Michael W. Manley, Nicole A. Becker et al. · Nucleic Acids Research · 2012 · 93 citations · Full text

, , +15

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

Brent W. Anderson, Kuanqing Liu, Christine Wolak et al. · eLife · 2019 · 47 citations · Full text

, , +17

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

Nikoloz Shkriabai, Venkatasubramanian Dharmarajan, Alison Slaughter et al. · Journal of Biological Chemistry · 2014 · 31 citations · Full text

, , +16

1–5 of 10

Authors

65

  1. OG
    Oliver G. Ottmann

    Goethe University Frankfurt, Germany

    1 publications · 31 citations

    1

    h-index

  2. MF
    Md. Faiz Ahmad

    Case Western Reserve University, United States

    1 publications · 176 citations

    1

    h-index

  3. CD
    Chris Dealwis

    Case Western Reserve University, United States

    1 publications · 176 citations

    1

    h-index

  4. MD
    Melanie D. Ohi

    Vanderbilt University, United States

    1 publications · 17 citations

    1

    h-index

  5. VD
    Venkatasubramanian Dharmarajan

    Scripps Research Institute, United States

    1 publications · 31 citations

    1

    h-index

1–5 of 65

Institutions

21

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    4 publications

    378 citations

  2. University of Tennessee at Knoxville

    Knoxville, United States

    1 h-index

    1 publications

    176 citations

  3. Harvard University

    Cambridge, United States

    1 h-index

    2 publications

    352 citations

  4. Medical Research Council

    London, United Kingdom

    1 h-index

    2 publications

    24 citations

  5. The Ohio State University

    Columbus, United States

    1 h-index

    7 publications

    217 citations

  6. Texas A&M University

    College Station, United States

    1 h-index

    2 publications

    56 citations

  7. Scripps Research Institute

    San Diego, United States

    1 h-index

    2 publications

    62 citations

  8. Karolinska Institutet

    Stockholm, Sweden

    1 h-index

    4 publications

    704 citations

1–8 of 21

Venues

  1. Biochemistry

    2 publications · 41 citations

    2

    h-index

  2. Nature Structural & Molecular Biology

    2 publications · 285 citations

    2

    h-index

  3. Leukemia

    1 publications · 31 citations

    1

    h-index

  4. Cell chemical biology

    1 publications · 17 citations

    1

    h-index

  5. Nucleic Acids Research

    1 publications · 93 citations

    1

    h-index

1–5