Concepedia

Allosteric Enzyme Engineering

Allosteric Enzyme Engineering is a methodological framework within protein engineering that involves the rational design or directed evolution of enzymes to introduce or modulate allosteric regulation by engineering binding sites and conformational dynamics that enable activity control through effector molecules.

31

Publications

1.6K

Citations

133

Authors

46

Institutions

Publications per year

2017–2026

4

Parents

Publications

31

DNA Detection and Signal Amplification via an Engineered Allosteric Enzyme

Alan Saghatelian, Kevin M. Guckian, Desiree A. Thayer et al. · Journal of the American Chemical Society · 2002 · 191 citations · Full text

, , +17

Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

Andrew R. Buller, Sabine Brinkmann‐Chen, David K. Romney et al. · Proceedings of the National Academy of Sciences · 2015 · 177 citations · Full text

, , +16

Creation of an Allosteric Enzyme by Domain Insertion

Gurkan Guntas, Marc Ostermeier · Journal of Molecular Biology · 2003 · 145 citations

, , +14

Allosteric nucleic acid catalysts

Garrett A. Soukup, Ronald R. Breaker · Current Opinion in Structural Biology · 2000 · 123 citations · Full text

, , +17

Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

Jae‐Seong Yang, Sang Woo Seo, Sungho Jang et al. · PLoS Computational Biology · 2012 · 86 citations · Full text

, , +17

1–5 of 31

Authors

133

  1. MO
    Marc Ostermeier

    Johns Hopkins University, United States

    3 publications · 257 citations

    3

    h-index

  2. AZ
    An‐Ping Zeng

    Hamburg University of Technology, Germany

    2 publications · 95 citations

    2

    h-index

  3. KK
    K Kunai

    The University of Tokyo, Japan

    1 publications · 24 citations

    1

    h-index

  4. AS
    Alan Saghatelian

    Salk Institute for Biological Studies, United States

    1 publications · 191 citations

    1

    h-index

  5. SH
    Shu-Wan Huang

    Kaohsiung Medical University, Taiwan

    1 publications · 13 citations

    1

    h-index

1–5 of 133

Institutions

46

  1. Johns Hopkins University

    Baltimore, United States

    3 h-index

    11 publications

    774 citations

  2. Jilin University

    Changchun, China

    3 h-index

    17 publications

    289 citations

  3. Hamburg University of Technology

    Hamburg, Germany

    2 h-index

    8 publications

    395 citations

  4. Universität Hamburg

    Hamburg, Germany

    2 h-index

    5 publications

    230 citations

  5. Peking University

    Beijing, China

    2 h-index

    2 publications

    122 citations

  6. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    5 publications

    191 citations

  7. Johns Hopkins Medicine

    Baltimore, United States

    1 h-index

    4 publications

    304 citations

  8. Qufu Normal University

    Qufu, China

    1 h-index

    5 publications

    150 citations

1–8 of 46

Venues

  1. Journal of the American Chemical Society

    JACS · 3 publications · 297 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 284 citations

    3

    h-index

  3. Protein Science

    PS · 3 publications · 69 citations

    3

    h-index

  4. Journal of Molecular Biology

    JMB · 2 publications · 158 citations

    2

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 30 citations

    2

    h-index

1–5