Concepedia

Allosteric Engineering

Allosteric Engineering is a protein engineering strategy that involves the rational design or directed evolution of allosteric sites in enzymes to modulate their activity, specificity, or regulatory properties in response to effector molecules.

36

Publications

2.3K

Citations

170

Authors

56

Institutions

Publications per year

2017–2026

8

Parents

Publications

36

Surface Sites for Engineering Allosteric Control in Proteins

Jeeyeon Lee, Madhusudan Natarajan, Vishal Nashine et al. · Science · 2008 · 346 citations

, , +17

Allosteric Supramolecular Triple-Layer Catalysts

Hyo Jae Yoon, Junpei Kuwabara, Jun‐Hyun Kim et al. · Science · 2010 · 316 citations

, , +15

Engineered allosteric activation of kinases in living cells

Andrei V. Karginov, Feng Ding, Pradeep Kota et al. · Nature Biotechnology · 2010 · 208 citations · Full text

, , +14

Allosteric nucleic acid catalysts

Garrett A. Soukup, Ronald R. Breaker · Current Opinion in Structural Biology · 2000 · 123 citations · Full text

, , +17

Allosteric Regulation of Phosphate Diester Transesterification Based upon a Dinuclear Zinc Catalyst Assembled via the Weak-Link Approach

Hyo Jae Yoon, Jungseok Heo, Chad A. Mirkin · Journal of the American Chemical Society · 2007 · 85 citations

, , +16

1–5 of 36

Authors

170

  1. NV
    Nikolay V. Dokholyan

    University of North Carolina at Chapel Hill, United States

    3 publications · 338 citations

    3

    h-index

  2. KM
    Klaus M. Hahn

    University of North Carolina at Chapel Hill, United States

    3 publications · 338 citations

    3

    h-index

  3. PK
    Pradeep Kota

    University of North Carolina at Chapel Hill, United States

    2 publications · 267 citations

    2

    h-index

  4. HJ
    Hyo Jae Yoon

    Korea University, South Korea

    2 publications · 401 citations

    2

    h-index

  5. AV
    Andrei V. Karginov

    University of Illinois Chicago, United States

    2 publications · 267 citations

    2

    h-index

1–5 of 170

Institutions

56

  1. Harvard University

    Cambridge, United States

    4 h-index

    10 publications

    672 citations

  2. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    3 h-index

    11 publications

    1.4K citations

  3. University of California, San Francisco

    San Francisco, United States

    2 h-index

    6 publications

    308 citations

  4. Northwestern University

    Evanston, United States

    2 h-index

    7 publications

    1.5K citations

  5. Yale University

    New Haven, United States

    2 h-index

    6 publications

    334 citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    9 publications

    2.8K citations

  7. University of Bonn

    Bonn, Germany

    2 h-index

    3 publications

    154 citations

  8. Fox Chase Cancer Center

    Philadelphia, United States

    1 h-index

    2 publications

    66 citations

1–8 of 56

Venues

  1. Journal of the American Chemical Society

    JACS · 4 publications · 203 citations

    4

    h-index

  2. Journal of Molecular Biology

    JMB · 5 publications · 111 citations

    4

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 202 citations

    4

    h-index

  4. Archives of Biochemistry and Biophysics

    ABB · 2 publications · 31 citations

    2

    h-index

  5. Science

    2 publications · 662 citations

    2

    h-index

1–5