Concepedia

Allosteric Coupling

Allosteric Coupling is a biophysical mechanism whereby the binding of an effector molecule at an allosteric site differentially modulates the functional activity of a protein's orthosteric site through conformational or dynamic changes, thereby enabling long-range communication between spatially distinct regions of the protein.

276

Publications

15.2K

Citations

1.2K

Authors

419

Institutions

Publications per year

2017–2026

88

Parents

Publications

276

Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

Vincent J. Hilser, E. Brad Thompson · Proceedings of the National Academy of Sciences · 2007 · 408 citations · Full text

, , +17

On the nature of allosteric transitions: Implications of non-exclusive ligand binding

Merry M. Rubin, Jean‐Pierre Changeux · Journal of Molecular Biology · 1966 · 340 citations

, , +14

Light-activated DNA binding in a designed allosteric protein

Devin Strickland, Keith Moffat, Tobin R. Sosnick · Proceedings of the National Academy of Sciences · 2008 · 310 citations · Full text

, , +16

Nested cooperativity in the ATPase activity of the oligomeric chaperonin GroEL

Ofer Yifrach, Amnon Horovitz · Biochemistry · 1995 · 305 citations

, , +17

Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin

M. F. Perutz, Alan R. Fersht, Sanford R. Simon et al. · Biochemistry · 1974 · 287 citations

, , +8

1–5 of 276

Authors

1.2K

  1. DT
    D. Thirumalai

    University of Maryland, College Park, United States

    5 publications · 172 citations

    5

    h-index

  2. AH
    Amnon Horovitz

    Weizmann Institute of Science, Israel

    4 publications · 380 citations

    4

    h-index

  3. RJ
    Robert J. Fletterick

    University of California, San Francisco, United States

    4 publications · 195 citations

    4

    h-index

  4. DG
    David Giedroc

    Indiana University Bloomington, United States

    4 publications · 140 citations

    4

    h-index

  5. AW
    Aron W. Fenton

    University of Kansas Medical Center, United States

    4 publications · 82 citations

    4

    h-index

1–5 of 1.2K

Institutions

419

  1. University of Wisconsin–Madison

    Madison, United States

    10 h-index

    23 publications

    1.1K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    20 publications

    2.6K citations

  3. University of California San Diego

    San Diego, United States

    8 h-index

    17 publications

    1.3K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    29 publications

    1.9K citations

  5. University of Maryland, College Park

    College Park, United States

    7 h-index

    19 publications

    502 citations

  6. National Institutes of Health

    Bethesda, United States

    6 h-index

    12 publications

    817 citations

  7. Washington University in St. Louis

    St Louis, United States

    6 h-index

    23 publications

    928 citations

  8. Case Western Reserve University

    Cleveland, United States

    6 h-index

    17 publications

    1.3K citations

1–8 of 419

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 31 publications · 3.1K citations

    27

    h-index

  2. Journal of Biological Chemistry

    JBC · 32 publications · 1.8K citations

    24

    h-index

  3. Biochemistry

    22 publications · 1.3K citations

    17

    h-index

  4. Journal of the American Chemical Society

    JACS · 14 publications · 595 citations

    13

    h-index

  5. Journal of Molecular Biology

    JMB · 11 publications · 771 citations

    11

    h-index

1–5