Concepedia

Allosteric Cooperativity

Allosteric Cooperativity is a biochemical regulatory mechanism in multimeric proteins whereby the binding of a ligand at one subunit alters the conformational state and functional affinity of neighboring subunits through allosteric communication pathways within the quaternary structure.

134

Publications

17.5K

Citations

560

Authors

220

Institutions

Publications per year

2017–2026

16

Parents

Publications

134

On the nature of allosteric transitions: A plausible model

Jacques Monod, Jeffries Wyman, Jean‐Pierre Changeux · Journal of Molecular Biology · 1965 · 8.9K citations

, , +10

What is Cooperativity?

Christopher A. Hunter, Harry L. Anderson · Angewandte Chemie International Edition · 2009 · 794 citations

, , +17

Mechanisms of cooperativity and allosteric regulation in proteins

M. F. Perutz · Quarterly Reviews of Biophysics · 1989 · 636 citations

, , +12

Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

Kenji Kamata, Morihiro Mitsuya, T. Nishimura et al. · Structure · 2004 · 503 citations · Full text

, , +16

Molecular Code for Cooperativity in Hemoglobin

Gary K. Ackers, Michael L. Doyle, David Myers et al. · Science · 1992 · 321 citations

, , +17

1–5 of 134

Authors

560

  1. RJ
    Robert J. Suhadolnik

    Temple University, United States

    5 publications · 431 citations

    5

    h-index

  2. BM
    Bruce M. Chassy

    National Institute of Dental and Craniofacial Research, United States

    4 publications · 412 citations

    4

    h-index

  3. AM
    Ana M. Costero

    Universitat de València, Spain

    4 publications · 106 citations

    4

    h-index

  4. GV
    Gianluigi Veglia

    University of Minnesota, United States

    4 publications · 279 citations

    4

    h-index

  5. SS
    Susan S. Taylor

    University of California San Diego, United States

    4 publications · 279 citations

    4

    h-index

1–5 of 560

Institutions

220

  1. Einstein Medical Center Philadelphia

    Philadelphia, United States

    5 h-index

    10 publications

    869 citations

  2. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    7 publications

    177 citations

  3. University of Sheffield

    Sheffield, United Kingdom

    4 h-index

    11 publications

    1.3K citations

  4. University of Michigan

    Ann Arbor, United States

    4 h-index

    10 publications

    608 citations

  5. University of Minnesota

    Minneapolis, United States

    4 h-index

    18 publications

    772 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    4 publications

    222 citations

  7. University of Geneva

    Geneva, Switzerland

    3 h-index

    15 publications

    301 citations

  8. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    3 h-index

    6 publications

    1K citations

1–8 of 220

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 854 citations

    13

    h-index

  2. Biochemistry

    13 publications · 582 citations

    12

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 666 citations

    7

    h-index

  4. Journal of Molecular Biology

    JMB · 7 publications · 9.1K citations

    7

    h-index

  5. Journal of the American Chemical Society

    JACS · 7 publications · 470 citations

    7

    h-index

1–5