Concepedia

Alkylated Base Recognition

Alkylated Base Recognition is a molecular detection mechanism in DNA repair biology that specifically identifies and binds to alkylated nucleotide bases, thereby initiating the repair of alkylation-induced DNA damage through lesion-specific recognition pathways.

34

Publications

1.9K

Citations

119

Authors

53

Institutions

Publications per year

2017–2026

1

Parents

Publications

34

Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA

Albert Y. Lau, Orlando D. Schärer, Leona D. Samson et al. · Cell · 1998 · 289 citations · Full text

, , +13

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

Albert Y. Lau, Michael D. Wyatt, Brian Glassner et al. · Proceedings of the National Academy of Sciences · 2000 · 228 citations

, , +14

Determination of the base recognition positions of zinc fingers from sequence analysis.

G. H. Jacobs · The EMBO Journal · 1992 · 143 citations · Full text

, , +15

The Escherichia coli 3-Methyladenine DNA Glycosylase AlkA Has a Remarkably Versatile Active Site

Patrick O’Brien, Tom Ellenberger · Journal of Biological Chemistry · 2004 · 100 citations · Full text

, , +14

Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB

Bomina Yu, J.F. Hunt · Proceedings of the National Academy of Sciences · 2009 · 91 citations · Full text

, , +17

1–5 of 34

Authors

119

  1. DL
    Dale L. Boger

    Scripps Research Institute, United States

    2 publications · 145 citations

    2

    h-index

  2. DS
    Douglas S. Johnson

    Pfizer (United States), United States

    2 publications · 145 citations

    2

    h-index

  3. AY
    Albert Y. Lau

    Johns Hopkins University, United States

    2 publications · 517 citations

    2

    h-index

  4. TE
    Tom Ellenberger

    Harvard University, United States

    2 publications · 389 citations

    2

    h-index

  5. BF
    Brandt F. Eichman

    Vanderbilt University, United States

    2 publications · 103 citations

    2

    h-index

1–5 of 119

Institutions

53

  1. Harvard University

    Cambridge, United States

    5 h-index

    13 publications

    2.6K citations

  2. Institut Gustave Roussy

    Villejuif, France

    2 h-index

    2 publications

    53 citations

  3. Inserm

    Paris, France

    2 h-index

    8 publications

    137 citations

  4. Kyoto University

    Kyoto, Japan

    2 h-index

    15 publications

    260 citations

  5. Scripps Research Institute

    San Diego, United States

    2 h-index

    13 publications

    910 citations

  6. Institute of Biosciences and Bioresources

    Bari, Italy

    1 h-index

    6 publications

    174 citations

  7. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    4 publications

    232 citations

  8. University of Duisburg-Essen

    Essen, Germany

    1 h-index

    1 publications

    26 citations

1–8 of 53

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 416 citations

    4

    h-index

  2. Bioorganic & Medicinal Chemistry

    3 publications · 134 citations

    3

    h-index

  3. Nucleic Acids Research

    3 publications · 83 citations

    3

    h-index

  4. 2

    h-index

  5. Journal of the American Chemical Society

    JACS · 2 publications · 84 citations

    2

    h-index

1–5