Concepedia

Aggregation-prone Sequences

Aggregation-Prone Sequences is a structural bioinformatics construct referring to specific amino acid sequences within proteins that are inherently susceptible to driving protein misfolding and subsequent amyloid formation due to their high hydrophobicity, low net charge, and propensity for β-sheet formation.

107

Publications

10K

Citations

503

Authors

203

Institutions

Publications per year

2017–2026

38

Parents

Publications

107

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Oscar Conchillo‐Solé, Natalia Sánchez de Groot, Francesc Avilés et al. · BMC Bioinformatics · 2007 · 1.1K citations · Full text

, , +17

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

Sebastian Maurer‐Stroh, Maja Debulpaep, Nico Kuemmerer et al. · Nature Methods · 2010 · 689 citations · Full text

, , +16

Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases

Amol Pawar, Kateri F. DuBay, Jesús Zurdo et al. · Journal of Molecular Biology · 2005 · 585 citations

, , +17

Prediction of Aggregation-Prone Regions in Structured Proteins

Gian Gaetano Tartaglia, Amol Pawar, Silvia Campioni et al. · Journal of Molecular Biology · 2008 · 438 citations

, , +14

A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins

Antonios C. Tsolis, Vassiliki A. Iconomidou, Stavros J. Hamodrakas · PLoS ONE · 2013 · 328 citations · Full text

, , +17

1–5 of 107

Authors

503

  1. JS
    Joost Schymkowitz

    KU Leuven, Belgium

    8 publications · 1.1K citations

    8

    h-index

  2. SK
    Sandeep Kumar

    Pfizer (United States), United States

    8 publications · 459 citations

    8

    h-index

  3. FR
    Frédéric Rousseau

    KU Leuven, Belgium

    7 publications · 1K citations

    7

    h-index

  4. FC
    Fabrizio Chiti

    University of Florence, Italy

    6 publications · 1.4K citations

    6

    h-index

  5. RG
    Rodrigo Gallardo

    KU Leuven, Belgium

    4 publications · 230 citations

    4

    h-index

1–5 of 503

Institutions

203

  1. University of Florence

    Florence, Italy

    9 h-index

    20 publications

    2.6K citations

  2. KU Leuven

    Leuven, Belgium

    7 h-index

    56 publications

    3.4K citations

  3. Pfizer (United States)

    New York, United States

    6 h-index

    14 publications

    1.3K citations

  4. Indian Institute of Technology Madras

    Chennai, India

    5 h-index

    10 publications

    271 citations

  5. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    5 h-index

    23 publications

    7K citations

  6. VIB-KU Leuven Center for Brain & Disease Research

    Leuven, Belgium

    5 h-index

    44 publications

    2.9K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    28 publications

    690 citations

  8. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    14 publications

    5.8K citations

1–8 of 203

Venues

  1. Journal of Molecular Biology

    JMB · 7 publications · 1.6K citations

    7

    h-index

  2. PLoS Computational Biology

    6 publications · 531 citations

    6

    h-index

  3. Nature Communications

    6 publications · 535 citations

    6

    h-index

  4. Protein Science

    PS · 6 publications · 422 citations

    6

    h-index

  5. Biochemistry

    5 publications · 263 citations

    5

    h-index

1–5