Concepedia

Aggregation Hotspots

Aggregation Hotspots is a computational method in developability assessment that identifies specific regions within a protein sequence prone to intermolecular aggregation by analyzing local physicochemical properties and sequence-based descriptors distinct from global stability metrics.

23

Publications

3K

Citations

114

Authors

63

Institutions

Publications per year

2017–2026

9

Parents

Publications

23

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Oscar Conchillo‐Solé, Natalia Sánchez de Groot, Francesc Avilés et al. · BMC Bioinformatics · 2007 · 1.1K citations · Full text

, , +17

Prediction of Aggregation-Prone Regions in Structured Proteins

Gian Gaetano Tartaglia, Amol Pawar, Silvia Campioni et al. · Journal of Molecular Biology · 2008 · 438 citations

, , +14

AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures

Rafael Zambrano, Agata Szczasiuk, Jordi Pujols et al. · Nucleic Acids Research · 2015 · 253 citations · Full text

, , +17

Prediction of Aggregation Prone Regions of Therapeutic Proteins

Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser et al. · The Journal of Physical Chemistry B · 2010 · 204 citations

, , +17

Rapid and accurate in silico solubility screening of a monoclonal antibody library

Pietro Sormanni, Leanne Amery, Sofia Ekizoglou et al. · Scientific Reports · 2017 · 141 citations · Full text

, , +17

1–5 of 23

Authors

114

  1. MV
    Michele Vendruscolo

    University of Cambridge, United Kingdom

    3 publications · 623 citations

    3

    h-index

  2. PR
    Puneet Rawat

    Indian Institute of Technology Madras, India

    2 publications · 91 citations

    2

    h-index

  3. VK
    Veysel Kayser

    The University of Sydney, Australia

    2 publications · 283 citations

    2

    h-index

  4. BL
    Bernhardt L. Trout

    Massachusetts Institute of Technology, United States

    2 publications · 283 citations

    2

    h-index

  5. BH
    Bernhard Helk

    Novartis (Switzerland), Switzerland

    2 publications · 283 citations

    2

    h-index

1–5 of 114

Institutions

63

  1. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    9 publications

    2.2K citations

  2. Indian Institute of Technology Madras

    Chennai, India

    2 h-index

    5 publications

    244 citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    9 publications

    1.3K citations

  4. Tokyo Institute of Technology

    Tokyo, Japan

    2 h-index

    2 publications

    91 citations

  5. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    6 publications

    1.1K citations

  6. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    2 h-index

    9 publications

    7.3K citations

  7. Uniformed Services University of the Health Sciences

    Bethesda, United States

    1 h-index

    1 publications

    41 citations

  8. University of Shizuoka

    Shizuoka, Japan

    1 h-index

    1 publications

    28 citations

1–8 of 63

Venues

  1. Scientific Reports

    4 publications · 217 citations

    3

    h-index

  2. Nature Communications

    2 publications · 99 citations

    2

    h-index

  3. Nucleic Acids Research

    2 publications · 324 citations

    2

    h-index

  4. Journal of Molecular Biology

    JMB · 2 publications · 500 citations

    2

    h-index

  5. PLoS ONE

    1 publications · 73 citations

    1

    h-index

1–5