Concepedia

Affinity Retention

Affinity Retention is the preservation of the binding strength between an antibody and its target antigen following the process of antibody humanization, ensuring that the humanized variant maintains functional equivalence to the original non-human antibody.

94

Publications

5.8K

Citations

463

Authors

154

Institutions

Publications per year

2017–2026

12

Parents

Publications

94

Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use

Jean Claude Reubi, Jean-Claude Schär, Beatrice Waser et al. · European Journal of Nuclear Medicine and Molecular Imaging · 2000 · 1.1K citations

, , +15

Decreased Zinc Affinity of Amyotrophic Lateral Sclerosis‐Associated Superoxide Dismutase Mutants Leads to Enhanced Catalysis of Tyrosine Nitration by Peroxynitrite

John P. Crow, Jacinda B. Sampson, Yingxin Zhuang et al. · Journal of Neurochemistry · 1997 · 489 citations · Full text

, , +17

High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

Jerker Mårtensson, J. C. K. Lai, A Meister · Proceedings of the National Academy of Sciences · 1990 · 283 citations

, , +15

Nanoscale synthesis and affinity ranking

Nathan J. Gesmundo, Bérengère Sauvagnat, Patrick J. Curran et al. · Nature · 2018 · 214 citations

, , +13

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

Michael L. Dustin, David E. Golan, De‐Min Zhu et al. · Journal of Biological Chemistry · 1997 · 174 citations · Full text

, , +13

1–5 of 94

Authors

463

  1. NE
    Nicholas E. Powers

    University of Colorado Denver, United States

    2 publications · 48 citations

    2

    h-index

  2. TI
    Takashi Ishihara

    Kobe City Medical Center General Hospital, Japan

    2 publications · 70 citations

    2

    h-index

  3. AS
    Arne Skerra

    Technical University of Munich, Germany

    2 publications · 48 citations

    2

    h-index

  4. HY
    Hideaki Yoshida

    Sapporo Medical University, Japan

    2 publications · 70 citations

    2

    h-index

  5. AL
    Alexandra Lerchner

    Technical University of Munich, Germany

    2 publications · 48 citations

    2

    h-index

1–5 of 463

Institutions

154

  1. Harvard University

    Cambridge, United States

    5 h-index

    15 publications

    628 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    17 publications

    371 citations

  3. National Cancer Institute

    Bethesda, United States

    3 h-index

    5 publications

    96 citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    3 h-index

    11 publications

    1.7K citations

  5. Inserm

    Paris, France

    3 h-index

    8 publications

    230 citations

  6. Washington University in St. Louis

    St Louis, United States

    3 h-index

    6 publications

    474 citations

  7. Massachusetts General Hospital

    Boston, United States

    3 h-index

    24 publications

    606 citations

  8. Kyowa Kirin (Japan)

    Tokyo, Japan

    2 h-index

    9 publications

    294 citations

1–8 of 154

Venues

  1. Journal of Biological Chemistry

    JBC · 10 publications · 762 citations

    10

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 584 citations

    6

    h-index

  3. Biochemical Journal

    BJ · 6 publications · 151 citations

    6

    h-index

  4. Journal of Medicinal Chemistry

    5 publications · 158 citations

    5

    h-index

  5. Endocrinology

    5 publications · 159 citations

    5

    h-index

1–5