Concepedia

Affinity Optimization

Affinity Optimization is a methodological approach in biorecognition that enhances the binding strength and specificity between molecular partners through systematic modification of their interaction interfaces.

121

Publications

7.3K

Citations

737

Authors

215

Institutions

Publications per year

2017–2026

39

Parents

Publications

121

The Design of Leadlike Combinatorial Libraries

Simon J. Teague, A. M. Davis, Paul D. Leeson et al. · Angewandte Chemie International Edition · 1999 · 810 citations

, , +17

Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator

Kevin P. Baker, Bryan Edwards, Sarah Main et al. · Arthritis & Rheumatism · 2003 · 488 citations

, , +15

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization

Esther Drent, Maria Themeli, Renée Poels et al. · Molecular Therapy · 2017 · 288 citations · Full text

, , +17

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

Moreno Wichert, Nikolaus Krall, Willy Decurtins et al. · Nature Chemistry · 2015 · 219 citations

, , +14

Directed in Vitro Evolution and Crystallographic Analysis of a Peptide-binding Single Chain Antibody Fragment (scFv) with Low Picomolar Affinity

Christian Zahnd, Silvia Spinelli, Béatrice Luginbühl et al. · Journal of Biological Chemistry · 2004 · 185 citations · Full text

, , +17

1–5 of 121

Authors

737

  1. SP
    Sheldon Park

    University at Buffalo, State University of New York, United States

    3 publications · 231 citations

    3

    h-index

  2. JS
    Jörg Scheuermann

    ETH Zurich, Switzerland

    3 publications · 305 citations

    3

    h-index

  3. EF
    Ernesto Freire

    Johns Hopkins University, United States

    3 publications · 314 citations

    3

    h-index

  4. BT
    Bruce Tidor

    Massachusetts Institute of Technology, United States

    3 publications · 104 citations

    3

    h-index

  5. DF
    David F. Green

    Stony Brook University, United States

    3 publications · 104 citations

    3

    h-index

1–5 of 737

Institutions

215

  1. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    10 publications

    362 citations

  2. University at Buffalo, State University of New York

    Buffalo, United States

    4 h-index

    23 publications

    1.1K citations

  3. ETH Zurich

    Zurich, Switzerland

    3 h-index

    17 publications

    2K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    14 publications

    522 citations

  5. AlbaNova

    Stockholm, Sweden

    2 h-index

    8 publications

    296 citations

  6. University of California, San Francisco

    San Francisco, United States

    2 h-index

    5 publications

    778 citations

  7. University of Chicago

    Chicago, United States

    2 h-index

    11 publications

    294 citations

  8. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    8 publications

    3.5K citations

1–8 of 215

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 423 citations

    6

    h-index

  2. Journal of Biological Chemistry

    JBC · 5 publications · 518 citations

    5

    h-index

  3. Journal of Computer-Aided Molecular Design

    4 publications · 122 citations

    4

    h-index

  4. Chemistry - A European Journal

    3 publications · 107 citations

    3

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 3 publications · 203 citations

    3

    h-index

1–5