Concepedia

Affinity Maturation Libraries

Affinity Maturation Libraries is a specialized type of antibody library constructed through the introduction of targeted or random mutations into antibody genes, followed by selection processes, to systematically enhance the binding affinity of antibodies toward a specific antigen.

47

Publications

2.5K

Citations

349

Authors

99

Institutions

Publications per year

2017–2026

9

Parents

Publications

47

Tumor Imaging Using a Picomolar Affinity HER2 Binding Affibody Molecule

Anna Orlova, Mikaela Magnusson, Tove Eriksson et al. · Cancer Research · 2006 · 565 citations · Full text

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Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies

Patrick S. Daugherty, Gang Chen, Brent L. Iverson et al. · Proceedings of the National Academy of Sciences · 2000 · 244 citations

, , +17

Stepwise <i>in vitro</i> affinity maturation of Vitaxin, an α <sub>v</sub> β <sub>3</sub> -specific humanized mAb

Herren Wu, Gregory Beuerlein, Ying Nie et al. · Proceedings of the National Academy of Sciences · 1998 · 143 citations · Full text

, , +17

Affinity maturation of a Taq DNA polymerase specific affibody by helix shuffling

Elin Gunneriusson, Karin Nord, Mathias Uhlén et al. · Protein Engineering Design and Selection · 1999 · 138 citations · Full text

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The influence of antibody fragment format on phage display based affinity maturation of IgG

Miriam Steinwand, Patrick Droste, André Frenzel et al. · mAbs · 2013 · 110 citations · Full text

, , +17

1–5 of 47

Authors

349

  1. JD
    James D. Marks

    University of California, San Francisco, United States

    3 publications · 135 citations

    3

    h-index

  2. SS
    Stefan Ståhl

    KTH Royal Institute of Technology, Sweden

    3 publications · 678 citations

    3

    h-index

  3. HO
    Hiroyuki Oyama

    Kobe Pharmaceutical University, Japan

    2 publications · 47 citations

    2

    h-index

  4. IH
    Ingmarie Höidén‐Guthenberg

    Affibody (Sweden), Sweden

    2 publications · 638 citations

    2

    h-index

  5. PM
    Peter M. Tessier

    Rensselaer Polytechnic Institute, United States

    2 publications · 97 citations

    2

    h-index

1–5 of 349

Institutions

99

  1. KTH Royal Institute of Technology

    Stockholm, Sweden

    5 h-index

    16 publications

    1.7K citations

  2. AlbaNova

    Stockholm, Sweden

    3 h-index

    4 publications

    665 citations

  3. University of California, San Francisco

    San Francisco, United States

    3 h-index

    5 publications

    201 citations

  4. Uppsala University

    Uppsala, Sweden

    2 h-index

    8 publications

    2.6K citations

  5. Affibody (Sweden)

    Solna, Sweden

    2 h-index

    11 publications

    4.7K citations

  6. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    5 publications

    61 citations

  7. Scripps Research Institute

    San Diego, United States

    2 h-index

    2 publications

    41 citations

  8. San Francisco General Hospital

    San Francisco, United States

    2 h-index

    2 publications

    102 citations

1–8 of 99

Venues

  1. Protein Engineering Design and Selection

    PEDS · 9 publications · 396 citations

    9

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 466 citations

    4

    h-index

  3. PLoS ONE

    3 publications · 113 citations

    3

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 98 citations

    3

    h-index

  5. mAbs

    2 publications · 139 citations

    2

    h-index

1–5