Concepedia

Adenosine Checkpoint Pathway

The "Adenosine Checkpoint Pathway" is a regulatory immune checkpoint mechanism in which extracellular adenosine, generated in the tumor microenvironment, suppresses anti-tumor immune responses through engagement of adenosine receptors on immune cells, thereby distinguishing it from other checkpoint pathways by its reliance on adenosine-mediated signaling.

11

Publications

806

Citations

179

Authors

72

Institutions

Publications per year

2017–2026

10

Parents

Publications

11

Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer

Lawrence Fong, Andrew Hotson, John D. Powderly et al. · Cancer Discovery · 2019 · 339 citations · Full text

, , +17

Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

Jia‐Cheng Lu, Pengfei Zhang, Xiaoyong Huang et al. · Journal of Hematology & Oncology · 2021 · 172 citations · Full text

, , +17

CD39+ regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function

Filip Ahlmanner, Patrik Sundström, Paulina Akéus et al. · Oncotarget · 2018 · 72 citations · Full text

, , +17

Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non–small-cell Lung Cancer

Anders Tøndell, Sissel Gyrid Freim Wahl, Anne‐Marit Sponaas et al. · Translational Oncology · 2019 · 53 citations · Full text

, , +17

Tumor CD73/A2aR adenosine immunosuppressive axis and tumor‐infiltrating lymphocytes in diffuse large B‐cell lymphoma: correlations with clinicopathological characteristics and clinical outcome

Xianhuo Wang, Tingting Zhang, Zheng Song et al. · International Journal of Cancer · 2019 · 40 citations · Full text

, , +17

1–5 of 11

Authors

179

  1. GG
    Ginna G. Laport

    Stanford University, United States

    1 publications · 339 citations

    1

    h-index

  2. II
    Ignacio I. Wistuba

    The University of Texas MD Anderson Cancer Center, United States

    1 publications · 26 citations

    1

    h-index

  3. PK
    Paulus Kristanto

    Université Libre de Bruxelles, Belgium

    1 publications · 27 citations

    1

    h-index

  4. PZ
    Pengfei Zhang

    University of California, Davis, United States

    1 publications · 172 citations

    1

    h-index

  5. JE
    Jenny Eklöf

    University of Gothenburg, Sweden

    1 publications · 72 citations

    1

    h-index

1–5 of 179

Institutions

72

  1. Université Libre de Bruxelles

    Brussels, Belgium

    2 h-index

    23 publications

    600 citations

  2. University of Nebraska Medical Center

    Omaha, United States

    2 h-index

    3 publications

    419 citations

  3. Institut Jules Bordet

    Brussels, Belgium

    2 h-index

    23 publications

    600 citations

  4. Fudan University Shanghai Cancer Center

    Shanghai, China

    2 h-index

    21 publications

    2.3K citations

  5. Yale Cancer Center

    New Haven, United States

    1 h-index

    1 publications

    339 citations

  6. University Medical Center Groningen

    Groningen, The Netherlands

    1 h-index

    7 publications

    98 citations

  7. Centre Hospitalier Universitaire de Tivoli

    La Louvière, Belgium

    1 h-index

    1 publications

    27 citations

  8. Sun Yat-sen University

    Guangzhou, China

    1 h-index

    12 publications

    2.1K citations

1–8 of 72

Venues

  1. Cancer Discovery

    2 publications · 355 citations

    2

    h-index

  2. Nature Communications

    1 publications · 27 citations

    1

    h-index

  3. Journal of Hematology & Oncology

    1 publications · 172 citations

    1

    h-index

  4. Frontiers in Oncology

    1 publications · 26 citations

    1

    h-index

  5. Journal for ImmunoTherapy of Cancer

    JITC · 1 publications · 14 citations

    1

    h-index

1–5