Concepedia

Activity-dependent Synaptic Refinement

Activity-Dependent Synaptic Refinement is a neurodevelopmental mechanism whereby synaptic connections in the nervous system are selectively stabilized or eliminated based on neural activity patterns, distinguishing it from activity-independent pruning processes by its reliance on functional input to shape synaptic architecture.

59

Publications

6.5K

Citations

223

Authors

94

Institutions

Publications per year

2017–2026

11

Parents

Publications

59

Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Takao K. Hensch, Michela Fagiolini, Nobuko Mataga et al. · Science · 1998 · 923 citations · Full text

, , +17

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

Joseph A. Gally, P. Read Montague, George N. Reeke et al. · Proceedings of the National Academy of Sciences · 1990 · 648 citations

, , +17

Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice

Fen-Lei F. Chang, William T. Greenough · Brain Research · 1984 · 527 citations

, , +17

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

Ana C. Barbosa, Mi-Sung Kim, Mert Ertunç et al. · Proceedings of the National Academy of Sciences · 2008 · 310 citations · Full text

, , +17

Molecular Modification of N-Cadherin in Response to Synaptic Activity

Hidekazu Tanaka, Weisong Shan, Greg R. Phillips et al. · Neuron · 2000 · 305 citations · Full text

, , +14

1–5 of 59

Authors

223

  1. HK
    Haig Keshishian

    Yale University, United States

    3 publications · 99 citations

    3

    h-index

  2. BB
    Benedikt Berninger

    Johannes Gutenberg University Mainz, Germany

    2 publications · 335 citations

    2

    h-index

  3. HC
    Hayeon C Oak

    University of California, San Francisco, United States

    2 publications · 196 citations

    2

    h-index

  4. TL
    Tao Li

    University of California, San Francisco, United States

    2 publications · 196 citations

    2

    h-index

  5. SG
    Stefanie Giera

    Boston Children's Hospital, United States

    2 publications · 196 citations

    2

    h-index

1–5 of 223

Institutions

94

  1. Harvard University

    Cambridge, United States

    5 h-index

    27 publications

    2.7K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    4 publications

    236 citations

  3. Yale University

    New Haven, United States

    3 h-index

    8 publications

    310 citations

  4. University of California, San Francisco

    San Francisco, United States

    3 h-index

    13 publications

    1.6K citations

  5. Japan Science and Technology Agency

    Tokyo, Japan

    3 h-index

    5 publications

    372 citations

  6. Vanderbilt University

    Nashville, United States

    3 h-index

    5 publications

    505 citations

  7. The University of Tokyo

    Tokyo, Japan

    3 h-index

    12 publications

    729 citations

  8. Boston Children's Hospital

    Boston, United States

    3 h-index

    20 publications

    2K citations

1–8 of 94

Venues

  1. Journal of Neuroscience

    12 publications · 634 citations

    12

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 1.4K citations

    6

    h-index

  3. Cell Reports

    4 publications · 242 citations

    4

    h-index

  4. Neuron

    4 publications · 797 citations

    4

    h-index

  5. Journal of Neurophysiology

    JN · 3 publications · 135 citations

    3

    h-index

1–5