Concepedia

Active Site Loop Engineering

Active Site Loop Engineering is a protein engineering strategy that involves the targeted modification of flexible loop regions surrounding the active site of an enzyme to modulate substrate access, specificity, or catalytic efficiency.

10

Publications

519

Citations

64

Authors

30

Institutions

Publications per year

2017–2026

5

Parents

Publications

10

Potent Inhibitors of β-Tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold

Panumart Thongyoo, Camille Bonomelli, Robin J. Leatherbarrow et al. · Journal of Medicinal Chemistry · 2009 · 128 citations · Full text

, , +16

Active-site loop variations adjust activity and selectivity of the cumene dioxygenase

Peter M. Heinemann, Daniel Armbruster, Bernhard Hauer · Nature Communications · 2021 · 95 citations · Full text

, , +17

Conformational Dynamics‐Guided Loop Engineering of an Alcohol Dehydrogenase: Capture, Turnover and Enantioselective Transformation of Difficult‐to‐Reduce Ketones

Beibei Liu, Ge Qu, Jun‐Kuan Li et al. · Advanced Synthesis & Catalysis · 2019 · 93 citations

, , +17

Substitutions in an Active Site Loop of Escherichia coli IscS Result in Specific Defects in Fe-S Cluster and Thionucleoside Biosynthesis in Vivo

Charles T. Lauhon, Elizabeth Skovran, Hugo D. Urbina et al. · Journal of Biological Chemistry · 2004 · 46 citations · Full text

, , +7

Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition

Maureen E. Hill, Derek MacPherson, Peng Wu et al. · ACS Chemical Biology · 2016 · 40 citations · Full text

, , +17

1–5 of 10

Authors

64

  1. MK
    Matthijs Kol

    Utrecht University, Netherlands

    1 publications · 12 citations

    1

    h-index

  2. OJ
    Olivier Julien

    University of Alberta, Canada

    1 publications · 40 citations

    1

    h-index

  3. GQ
    Ge Qu

    Tianjin Institute of Industrial Biotechnology, China

    1 publications · 93 citations

    1

    h-index

  4. LV
    Leonie van Suijlekom

    Utrecht University, Netherlands

    1 publications · 12 citations

    1

    h-index

  5. HC
    Haifeng Chen

    Shanghai Jiao Tong University, China

    1 publications · 35 citations

    1

    h-index

1–5 of 64

Institutions

30

  1. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    7 publications

    517 citations

  2. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    2 h-index

    7 publications

    517 citations

  3. University of Cape Town

    Rondebosch, South Africa

    1 h-index

    1 publications

    20 citations

  4. Tianjin University

    Tianjin, China

    1 h-index

    2 publications

    186 citations

  5. Collaborative Innovation Center of Chemical Science and Engineering Tianjin

    Tianjin, China

    1 h-index

    2 publications

    186 citations

  6. Pontificia Universidad Católica de Chile

    Santiago, Chile

    1 h-index

    3 publications

    72 citations

  7. Millennium Institute for Integrative Biology

    Santiago, Chile

    1 h-index

    3 publications

    72 citations

  8. Oregon Health & Science University

    Portland, United States

    1 h-index

    1 publications

    12 citations

1–8 of 30

Venues

  1. ACS Chemical Biology

    2 publications · 75 citations

    2

    h-index

  2. Journal of Biological Chemistry

    JBC · 1 publications · 46 citations

    1

    h-index

  3. Journal of Medicinal Chemistry

    1 publications · 128 citations

    1

    h-index

  4. Journal of Lipid Research

    JLR · 1 publications · 12 citations

    1

    h-index

  5. Advanced Synthesis & Catalysis

    1 publications · 93 citations

    1

    h-index

1–5