Concepedia

A1 Function

A1 Function is a regulatory protein activity within the Bcl-2 family that selectively modulates mitochondrial outer membrane permeabilization to promote cell survival by inhibiting pro-apoptotic Bcl-2 family members.

43

Publications

2.6K

Citations

233

Authors

93

Institutions

Publications per year

2017–2026

6

Parents

Publications

43

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

Raelene J. Grumont, Ian J. Rourke, Steve Gerondakis · Genes & Development · 1999 · 398 citations · Full text

, , +17

Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells

Aly Karsan, Esther Yee, K Kaushansky et al. · Blood · 1996 · 173 citations · Full text

, , +16

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M. Carrington, Yifan Zhan, Jamie L. Brady et al. · Cell Death and Differentiation · 2017 · 155 citations · Full text

, , +11

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation

EY Lin, Amos Orlofsky, JC Reed et al. · Blood · 1996 · 146 citations · Full text

, , +9

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

Malgorzata Nieborowska-Skorska, Grażyna Hoser, Plamen Kossev et al. · Blood · 2002 · 113 citations · Full text

, , +16

1–5 of 43

Authors

233

  1. AK
    Aly Karsan

    University of British Columbia, Canada

    4 publications · 378 citations

    4

    h-index

  2. MJ
    Marco J. Herold

    Walter and Eliza Hall Institute of Medical Research, Australia

    4 publications · 311 citations

    4

    h-index

  3. AO
    Amos Orlofsky

    Albert Einstein College of Medicine, United States

    3 publications · 197 citations

    3

    h-index

  4. AM
    Andrew M. Lew

    Walter and Eliza Hall Institute of Medical Research, Australia

    2 publications · 227 citations

    2

    h-index

  5. IB
    Ingolf Berberich

    University of Würzburg, Germany

    2 publications · 144 citations

    2

    h-index

1–5 of 233

Institutions

93

  1. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    5 h-index

    36 publications

    4.9K citations

  2. The University of Melbourne

    Melbourne, Australia

    4 h-index

    31 publications

    3.5K citations

  3. University of Washington

    Seattle, United States

    3 h-index

    9 publications

    1.1K citations

  4. Albert Einstein College of Medicine

    Bronx, United States

    3 h-index

    12 publications

    788 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    10 publications

    566 citations

  6. Innsbruck Medical University

    Innsbruck, Austria

    2 h-index

    7 publications

    244 citations

  7. University of British Columbia

    Vancouver, Canada

    2 h-index

    5 publications

    480 citations

  8. Zhejiang Chinese Medical University

    Hangzhou, China

    2 h-index

    6 publications

    205 citations

1–8 of 93

Venues

  1. Cell Death and Differentiation

    CDD · 5 publications · 308 citations

    5

    h-index

  2. Journal of Biological Chemistry

    JBC · 4 publications · 298 citations

    4

    h-index

  3. Blood

    3 publications · 432 citations

    3

    h-index

  4. FEBS Letters

    2 publications · 109 citations

    2

    h-index

  5. Molecular and Cellular Biology

    MCB · 2 publications · 57 citations

    2

    h-index

1–5