Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G. House, +17

Nature Immunology

Tumor ImmunologyCancer ImmunosurveillanceT CellsImmunologyTumor Immunity +9

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M. Carrington, Yifan Zhan, Jamie L. Brady, +15

Cell Death and Differentiation

Autoimmune DiseaseApoptosisImmunologyTumor ImmunityCell Death +8

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

Emma M. Carrington, Ingela B. Vikstrom, Amanda Light, +6

Proceedings of the National Academy of Sciences

GM‐CSF increases cross‐presentation and CD103 expression by mouse CD8⁺ spleen dendritic cells

Yifan Zhan, Emma M. Carrington, Annemarie van Nieuwenhuijze, +8

European Journal of Immunology

Adaptive Immune SystemImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +18

Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells

Susan Johnson, Yifan Zhan, Robyn M. Sutherland, +8

Immunity

Toll-like ReceptorsAutoimmune DiseaseT-regulatory CellImmunologyAntiviral Response +7

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells

Mark McKenzie, Emma M. Carrington, Thomas Kaufmann, +5

Diabetes

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L. Schenk, Selma Tuzlak, Emma M. Carrington, +9

Cell Death and Differentiation

Knockout MouseHaematopoietic CompartmentLymphocyte DevelopmentHematologyImmunology +8

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Paul Koenen, Susanne Heinzel, Emma M. Carrington, +8

Nature Communications

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

Ingela B. Vikstrom, Anne Slomp, Emma M. Carrington, +11

Cell Death and Disease

Rotavirus Infection of Infant and Young Adult Nonobese Diabetic Mice Involves Extraintestinal Spread and Delays Diabetes Onset

Kate L. Graham, Joanne A. O’Donnell, Yan Tan, +4

Journal of Virology

Type 1Rotavirus AntigenAutoimmune DiseaseViral PersistenceRotavirus Strain Rrv +11