Brian Long

Strategy to detect pre-existing immunity to AAV gene therapy

Lillian Falese, Krystal Sandza, Bridget Yates et al. · Gene Therapy · 2017 · 99 citations · Full text

Life Sciences, Hematology, Immunology +13

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 – Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)

Steven P. Piccoli, Devangi Mehta, Alessandra Vitaliti et al. · Bioanalysis · 2019 · 95 citations · Full text

Pharmacy, Biomedical Sciences, Biopharmaceutics +13

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy

Brian Long, Krystal Sandza, Jennifer Holcomb et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 76 citations · Full text

Life Sciences, Immunology, Pharmacology +13

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A

Brian Long, P. Véron, Klaudia Kuranda et al. · Molecular Therapy · 2020 · 73 citations · Full text

Medicine, Hematology, Immunology +11

Deciphering conundrums of adeno-associated virus liver-directed gene therapy: focus on hemophilia

Glenn F. Pierce, Sylvia Fong, Brian Long et al. · Journal of Thrombosis and Haemostasis · 2023 · 45 citations

Life Sciences, Hematology, Molecular Biology +13