Brian Long

Strategy to detect pre-existing immunity to AAV gene therapy

Lillian Falese, Krystal Sandza, Bridget Yates et al. · Gene Therapy · 2017 · 97 citations · Full text

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 – Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)

Steven P. Piccoli, Devangi Mehta, Alessandra Vitaliti et al. · Bioanalysis · 2019 · 92 citations · Full text

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy

Brian Long, Krystal Sandza, Jennifer Holcomb et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 75 citations · Full text

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A

Brian Long, P. Véron, Klaudia Kuranda et al. · Molecular Therapy · 2020 · 71 citations · Full text

Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates

Fan Yang, Kathryn Patton, Theresa Kasprzyk et al. · Gene Therapy · 2021 · 41 citations · Full text