M M Simile

Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC

Diego F. Calvisi, Federico Pinna, Sara Ladu et al. · Gut · 2009 · 90 citations

Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat liver during the early stages of hepatocarcinogenesis.

Rosa M. Pascale, M M Simile, G Satta et al. · PubMed · 1992 · 88 citations

Preneoplastic Lesions, Dna Methylation, Pathology +22

Chemoprevention by <i>S</i>-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid

Rosa M. Pascale, M M Simile, Maria R. De Miglio et al. · Carcinogenesis · 1995 · 75 citations

Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells

M M Simile · Carcinogenesis · 2003 · 63 citations · Full text

Correlation between S-adenosyl-l-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis

M M Simile, Rosa M. Pascale, Maria R. De Miglio et al. · Cancer Letters · 1994 · 59 citations

Hepatology, Hepatocellular Carcinoma, Oncogenic Agent +13