Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding

Hui Zhou, Shiyi Zhou, Merritt Gillilland, +6

JCI Insight

Escherichia coli Promotes Endothelial to Mesenchymal Transformation of Liver Sinusoidal Endothelial Cells and Exacerbates Nonalcoholic Fatty Liver Disease Via Its Flagellin

Bo Shen, Tianyi Gu, Zhenyang Shen, +10

Cellular and Molecular Gastroenterology and Hepatology

InflammationVirulence FactorLiver PhysiologyPathogenesisImmunology +11

Bile acids elevated by high-fat feeding induce endoplasmic reticulum stress in intestinal stem cells and contribute to mucosal barrier damage

Dan Huang, Xiong Min-li, Xianjun Xu, +5

Biochemical and Biophysical Research Communications

Bile AcidsHigh-fat FeedingBiliary TractLiver PhysiologyPhysiology +9

Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis

Bo Shen, Junjun Wang, Yuecheng Guo, +10

Frontiers in Microbiology

FABP4 in LSECs promotes CXCL10-mediated macrophage recruitment and M1 polarization during NAFLD progression

Cui Zhou, Zhenyang Shen, Bo Shen, +11

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

InflammationSignal TransductionSignaling PathwayCell RegulationCell Signaling +8

Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7‐mediated degradation of <scp>TGFβRI</scp>

Xianjun Xu, Yuecheng Guo, Xin Luo, +13

Liver International

Recent progress in fluorescent probes for Cu2+ based on small organic molecules

Liqiang Yan, Kaiyue Bao, Xianjun Xu, +2

Journal of Molecular Structure

Small Organic MoleculesChemical EngineeringRecent ProgressChemistryChemical Probe +4

Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach

Xianjun Xu, Jinnian Cheng, Shengzheng Luo, +6

Biochemical and Biophysical Research Communications

ImmunologyGastroenterologyCell DeathAutophagyPathology +7

An elevated deoxycholic acid level induced by high-fat feeding damages intestinal stem cells by reducing the ileal IL-22

Jingxian Xu, Dan Huang, Xianjun Xu, +5

Biochemical and Biophysical Research Communications

InflammationNutritionPhysiologyImmunologyGastroenterology +5

Expansion of macrophage and liver sinusoidal endothelial cell subpopulations during non-alcoholic steatohepatitis progression

Zhenyang Shen, Bo Shen, Weiming Dai, +9

iScience