Jürgen Hinrichs

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Stéphane Ferretti, Jacques Hamon, Ruben de Kanter et al. · Nature · 2024 · 94 citations · Full text

Total Synthesis and Structural Elucidation of Azaspiracid-1. Construction of Key Building Blocks for Originally Proposed Structure

K. C. Nicolaou, Petri M. Pihko, Federico Bernal et al. · Journal of the American Chemical Society · 2006 · 71 citations

Atropo-Enantioselective Synthesis of the Natural Bicoumarin (+)-Isokotanin A via a Configurationally Stable Biaryl Lactone

Gerhard Bringmann, Jürgen Hinrichs, Petra Henschel et al. · European Journal of Organic Chemistry · 2002 · 60 citations

Chiral Bicoumarin, Atroposelective Ring Cleavage, Atropo-enantioselective Synthesis +15

Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

K. C. Nicolaou, Wenyuan Qian, Federico Bernal et al. · Angewandte Chemie International Edition · 2001 · 60 citations

From Dynamic to Non-Dynamic Kinetic Resolution of Lactone-Bridged Biaryls: Synthesis of Mastigophorene B

Gerhard Bringmann, Jürgen Hinrichs, Thomas Pabst et al. · Synthesis · 2001 · 46 citations

Stable Biaryl Lactones, Atroposelective Ring Cleavage, Lactone-bridged Biaryls +12