CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, +14

Cell

Cdk7-dependent Transcriptional AddictionBreast OncologyMedicineBreast CancerCancer Biology +3

Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

Jing Ni, Qingsong Liu, Shaozhen Xie, +9

Cancer Discovery

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

Yubao Wang, Youngmi Lee, Lukas Baitsch, +15

eLife

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Johann S. Bergholz, Qiwei Wang, Qi Wang, +19

Nature

Immune EvasionSignaling PathwayImmune RegulationTumor ImmunityImmunology +6

PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context

Fabienne Schmit, Tamara Utermark, Sen Zhang, +4

Proceedings of the National Academy of Sciences

Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α

Kira Gritsman, Haluk Yuzugullu, Thanh Von, +11

Journal of Clinical Investigation

Pi3k Isoform P110αPathologyCell DeathCancer BiologyDownstream Pi3k +18

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

Haluk Yuzugullu, Lukas Baitsch, Thanh Von, +8

Nature Communications

PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers

Qīng Wáng, P Liu, Jennifer M. Spangle, +6

Oncogene

Tumor BiologyBreast OncologyHer2-targeted TherapyMedicineCancer Cell Biology +9

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation

Andrew G. Li, Elizabeth C. Murphy, Aedín C. Culhane, +12

Proceedings of the National Academy of Sciences

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways

Haluk Yuzugullu, Thanh Von, Lauren M. Thorpe, +4

Cell Discovery

ImmunologyImmune RegulationPten DeficiencyImmune SystemImmunotherapy +18