Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

Humsa S. Venkatesh, Lydia Tam, Pamelyn J. Woo, +9

Nature

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, +37

Cancer Discovery

Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

Jing Ni, Qingsong Liu, Shaozhen Xie, +9

Cancer Discovery

Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells

Lin Yang, Shaozhen Xie, Md Saha Jamaluddin, +9

Journal of Biological Chemistry

Androgen ReceptorApoptosisAr ExpressionCell DeathSignaling Pathway +17

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

Jing Ni, Shakti Ramkissoon, Shaozhen Xie, +22

Nature Medicine

Combination InhibitionPatient-derived XenograftsMedicineMice BearingBreast Cancer +6

Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery

Jing Ni, Ming Chen, Yu Zhang, +3

Biochemical and Biophysical Research Communications

Vitamin EChemoprevention StrategyMedicinePharmacologyCancer Prevention +5

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

Achira Roy, Jonathan Skibo, Franck Kalume, +8

eLife

Pi3k InhibitorsGliomaSocial SciencesTreatable EpilepsyBrain Enlargement +18

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

Qingsong Liu, Sivapriya Kirubakaran, Wooyoung Hur, +18

Journal of Biological Chemistry

Drug TargetAtp-competitive Mammalian TargetMolecular BiologyAtp-competitive Mtor InhibitorsChemical Biology +26

Tocopherol-Associated Protein Suppresses Prostate Cancer Cell Growth by Inhibition of the Phosphoinositide 3-Kinase Pathway

Jing Ni, Xingqiao Wen, Jorge L. Yao, +10

Cancer Research

Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas

Sharmistha Pal, David Kozono, Xiaodong Yang, +16

Cancer Research