Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

Youn Sook Lee, Jin Seok Park, Jun Hwan Kim, +4

Nature Communications

Smad6-specific RecruitmentSignal TransductionSignaling PathwayCell RegulationTgf-β1-induced Degradation +9

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1

Ji-Hyung Lee, Su Myung Jung, Kyung-Min Yang, +18

Nature Cell Biology

Breast OncologyMalignant DiseaseMedicinePathologyBreast Cancer +3

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

Su Myung Jung, Ji-Hyung Lee, Jinyoung Park, +10

Nature Communications

Transcriptional RegulationMolecular PhysiologySignal TransductionSignaling PathwayCell Regulation +7

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

Su Myung Jung, Chien‐Min Hung, Samuel Hildebrand, +14

Molecular Cell

Signal TransductionPhysiologyMetabolic RegulationNon-canonical Mtorc2Metabolism +4

Activin receptor‐like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

Jeong‐Hwan Yoon, Su Myung Jung, Seok Hee Park, +15

EMBO Molecular Medicine

A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells

Jin Seok Park, Minbeom Kim, No‐Joon Song, +9

Stem Cells

Adult Stem CellBone RepairOsteoporosisRegenerative MedicineTranscriptional Regulation +22

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway

Dongyeob Seo, Su Myung Jung, Jin Seok Park, +4

EBioMedicine

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis

Grace Park, John D. Haley, Johnny Le, +10

Nature Metabolism

Energy MetabolismBody CompositionMuscle FunctionBiochemistrySkeletal Muscle +8

In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

Su Myung Jung, Will Doxsey, Johnny Le, +6

Cell Reports

Vivo Isotope TracingMetabolic RemodelingInsulin SignalingOxidative StressObesity +18

Activin receptor‐like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic <scp>T</scp> lymphocytes

Jeong‐Hwan Yoon, Su Myung Jung, Seok Hee Park, +15

EMBO Molecular Medicine